INT294372

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.34
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc10a3)
Anatomy Link Frequency
muscle 1
Slc10a3 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 9 50.00 Quite Low
GABA receptor 9 9.56 Low Low
GABAergic 17 5.00 Very Low Very Low Very Low
Central nervous system 11 5.00 Very Low Very Low Very Low
amygdala 2 5.00 Very Low Very Low Very Low
potassium channel 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 36 94.76 High High
Diabetes Mellitus 3 52.88 Quite High
Sprains And Strains 8 50.08 Quite High
Hypertrophy 31 33.84 Quite Low
Aging 1 14.88 Low Low
Dislocations 5 5.00 Very Low Very Low Very Low
Ganglion Cysts 4 5.00 Very Low Very Low Very Low
Frailty 4 5.00 Very Low Very Low Very Low
Insulin Resistance 2 5.00 Very Low Very Low Very Low
Cicatrix 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the IGF1 gene set showed significant positive enrichment at P3 and negative enrichment at P13, suggesting a possible compensatory role at P3 upon loss of the ?
Positive_regulation (enrichment) of P3
1) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816210 Disease Relevance 0.13 Pain Relevance 0
This indicates that exercise-induced accumulation of PI(3,4,5)P3 was required for the activation of PKB following some types of contraction.
Positive_regulation (accumulation) of P3
2) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.06 Pain Relevance 0
To determine whether PI(3,4,5)P3 accumulation was important for resistance exercise-induced signalling to mTORC1 we therefore sought to determine the effect of muscle-specific knockout of the 3-phosphatase PTEN.
Spec (whether) Positive_regulation (accumulation) of P3 in muscle associated with targeted disruption
3) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.14 Pain Relevance 0

General Comments

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