INT294396

Context Info Confidence 0.45 First Reported 2010 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.43 Pain Relevance 0

plasma membrane (Vav2) intracellular (Vav2) cytoplasm (Vav2)

Anatomy Link Frequency eye 1 Vav2 (Mus musculus)

Pain Link Frequency Relevance Heat anesthesia 4 5.00 Inflammation 2 5.00

Disease Link Frequency Relevance Heat Glaucoma 108 99.32 Ocular Hypertension 114 95.88 Frailty 2 68.48 Syndrome 2 60.60 Disease 4 50.00 Hydrophthalmos 10 5.00 Ganglion Cysts 8 5.00 Targeted Disruption 6 5.00 Sprains And Strains 4 5.00 Optic Disorders 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In order to understand the pathogenesis of the Vav2/Vav3-deficient eye phenotype, we examined the mRNA and protein expression patterns of Vav2 and Vav3 in the eye (Figure 5).

Spec (examined) Regulation (patterns) of Vav2 in eye

1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.43 Pain Relevance 0

The most significant advantage of this mouse glaucoma model is that the deleted genes, Vav2 and Vav3, are well-focused targets that have been studied over 20 years providing a useful starting point for further investigation of the potential molecular mechanisms underlying this phenotype.

Regulation (targets) of Vav2 associated with glaucoma

2) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.99 Pain Relevance 0

General Comments

This test has worked.