INT294398

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Context Info
Confidence 0.78
First Reported 2010
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 26
Disease Relevance 10.67
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Vav2) intracellular (Vav2) cytoplasm (Vav2)
Anatomy Link Frequency
eye 6
retina 5
cornea 2
lens 1
sclera 1
Vav2 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 52 62.56 Quite High
Inflammation 26 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glaucoma 1404 99.76 Very High Very High Very High
Hydrophthalmos 130 99.60 Very High Very High Very High
Ocular Hypertension 1482 97.88 Very High Very High Very High
Targeted Disruption 78 97.12 Very High Very High Very High
Ganglion Cysts 104 96.88 Very High Very High Very High
Optic Disorders 52 87.04 High High
Adhesions 26 80.00 Quite High
Disease 52 75.00 Quite High
Blindness 26 72.16 Quite High
Frailty 26 37.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of Vav2 and Vav3 in Mouse and Human Eyes
Gene_expression (Expression) of Vav2 in Eyes
1) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.53 Pain Relevance 0
Vav3 mRNA was more abundantly expressed than that of Vav2 in the TM and the retina.
Gene_expression (expressed) of Vav2 in retina
2) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.38 Pain Relevance 0
The expression of Vav2 and Vav3 tissues was demonstrated in the iridocorneal angle and retina in both mouse and human eyes.
Gene_expression (expression) of Vav2 in eyes
3) Confidence 0.78 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2816215 Disease Relevance 0.96 Pain Relevance 0
Quantitative real-time PCR revealed that Vav2 and Vav3 mRNA are expressed in TM, cornea, retina, lens, iris, and ciliary body in the mouse eye (Figure 5A).
Gene_expression (expressed) of Vav2 in iris
4) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.41 Pain Relevance 0
In addition, since the expression of Vav2 and Vav3 was detected in ocular tissues other than those comprising the iridocorneal angle, it will be necessary in future studies to consider how their deficiency in these tissues might have potentially contributed to the spontaneous glaucoma phenotype in any way.
Gene_expression (expression) of Vav2 associated with glaucoma
5) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.92 Pain Relevance 0
Gene expression levels of both Vav2 and Vav3 in the eye were comparable to levels found in immune cells where Vavs play a critical role [5], [7]–[16].
Gene_expression (expression) of Vav2 in eye
6) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.31 Pain Relevance 0
We observed Vav2 and Vav3 proteins expression in the tissues of human iridocorneal angle and retina.
Gene_expression (expression) of Vav2 in retina
7) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.55 Pain Relevance 0
Vav1 is expressed specifically in lymphoid lineage cells, whereas Vav2 and Vav3 are more widely expressed [5], [7].
Gene_expression (expressed) of Vav2
8) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.59 Pain Relevance 0
Briefly, to detect mRNAs for Vav2 and Vav3, specific antisense oligonucleotide probes were synthesizedas follows:(2275–2319;45mers)5?
Gene_expression (detect) of Vav2
9) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0 Pain Relevance 0.06
Judging from alleric P-values distribution for detecting VAV2 ranking and genotypic P- values distribution for VAV3 ranking, we observed that VAV2 and VAV3 showed high scores (?
Gene_expression (ranking) of VAV2
10) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.86 Pain Relevance 0
Probes of mVav2 and mVav3 were TaqMan probes (Vav2: Mm00437287_m1, Vav3: Mm00445082_m1) purchased from Applied Biosystems (Foster city, CA).
Gene_expression (probes) of Vav2
11) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0 Pain Relevance 0
In mouse eyes, expression of both Vav2 and Vav3 was demonstrated in several ocular tissues including the iridocorneal angle, retina, cornea, and sclera.
Gene_expression (expression) of Vav2 in cornea
12) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.05 Pain Relevance 0
In order to understand the pathogenesis of the Vav2/Vav3-deficient eye phenotype, we examined the mRNA and protein expression patterns of Vav2 and Vav3 in the eye (Figure 5).
Spec (examined) Gene_expression (expression) of Vav2 in eye
13) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.43 Pain Relevance 0
The finding that Vav2-deficiency alone results in a glaucoma phenotype suggests that the absence of Vav2 plays a critical role in the development of this phenotype.
Neg (absence) Gene_expression (absence) of Vav2 associated with glaucoma
14) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.94 Pain Relevance 0
Gene expression levels of both Vav2 and Vav3 in the eye were comparable to levels found in immune cells where Vavs play a critical role [5], [7]–[16].
Gene_expression (levels) of Vav2 in eye
15) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.31 Pain Relevance 0
The co- localization of Vav2 and Vav3 mRNA expression in iridocorneal angle, such as TM, was confirmed by ISH.
Gene_expression (expression) of Vav2
16) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.05 Pain Relevance 0
Both Vav2 and Vav3 proteins were also expressed in human retina and iridocorneal angle.
Gene_expression (expressed) of Vav2 in retina
17) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.12 Pain Relevance 0
Loss of Vav2 and Vav3 expression is associated with changes in the iridocorneal angle, with eventual chronic angle closure.
Gene_expression (expression) of Vav2
18) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.77 Pain Relevance 0
Also, we assessed Vav2 and Vav3 protein expression by immunoblotting in both mouse and human eyes (Figure 5C).
Gene_expression (expression) of Vav2 in eyes
19) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0 Pain Relevance 0
Both were intronic SNPs, SNP rs2156323 lying in intron3 of VAV2 and SNP rs2801219 lying in intron1 of VAV3.
Gene_expression (lying) of VAV2
20) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.75 Pain Relevance 0

General Comments

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