INT294399

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Context Info
Confidence 0.59
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.59
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Vav3) intracellular (Vav3) cytoplasm (Vav3)
Anatomy Link Frequency
outflow 1
Vav3 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 114 99.82 Very High Very High Very High
Glaucoma 108 95.20 Very High Very High Very High
Blindness 2 89.64 High High
Disease 4 75.00 Quite High
Ganglion Cysts 8 74.08 Quite High
Frailty 2 44.92 Quite Low
Syndrome 2 37.04 Quite Low
Hydrophthalmos 10 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we demonstrate that deficiency of Vav2 and Vav3, guanine nucleotides exchange factors for Rho guanosine triphosphatases, leads to an ocular phenotype similar to human glaucoma.
Negative_regulation (deficiency) of Vav3 associated with glaucoma
1) Confidence 0.59 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2816215 Disease Relevance 0.70 Pain Relevance 0
While progressive angle closure may be the etiology prior to elevated IOP in mice lacking Vav2 and Vav3 function, it may alternatively be a subsequent change related to other alterations in angle structures which might also affect aqueous humor outflow.
Negative_regulation (lacking) of Vav3 in outflow associated with ocular hypertension
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.89 Pain Relevance 0

General Comments

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