INT294402

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Context Info
Confidence 0.48
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.43
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Vav3) intracellular (Vav3) cytoplasm (Vav3)
Vav3 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 8 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glaucoma 216 99.60 Very High Very High Very High
Ocular Hypertension 228 56.96 Quite High
Disease 8 50.00 Quite Low
Hydrophthalmos 20 5.00 Very Low Very Low Very Low
Ganglion Cysts 16 5.00 Very Low Very Low Very Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Sprains And Strains 8 5.00 Very Low Very Low Very Low
Optic Disorders 8 5.00 Very Low Very Low Very Low
Hyperplasia 4 5.00 Very Low Very Low Very Low
Syndrome 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to investigate the relevant association of VAV2 and VAV3 in human glaucoma patients, we carried out a genome-wide association study using the Affymetrix GeneChip Human Mapping 500 K Array Set.
VAV3 Binding (association) of associated with glaucoma
1) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.65 Pain Relevance 0
Judging from alleric P-values distribution for detecting VAV2 ranking and genotypic P- values distribution for VAV3 ranking, we observed that VAV2 and VAV3 showed high scores (?
VAV3 Binding (ranking) of
2) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.86 Pain Relevance 0
The most significant SNPs were chosen in this report to evaluate the association of VAV2, VAV3, and VAV1 in the cases.


VAV3 Binding (association) of
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.18 Pain Relevance 0
Both were intronic SNPs, SNP rs2156323 lying in intron3 of VAV2 and SNP rs2801219 lying in intron1 of VAV3.
VAV3 Binding (intron1) of
4) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.74 Pain Relevance 0

General Comments

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