INT294406

Context Info Confidence 0.50 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.73 Pain Relevance 0

plasma membrane (Vav2) intracellular (Vav2) cytoplasm (Vav2)

Vav2 (Mus musculus)

Pain Link Frequency Relevance Heat anesthesia 2 5.00 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Glaucoma 54 98.36 Blindness 1 89.64 Ocular Hypertension 57 85.52 Ganglion Cysts 4 80.40 Disease 2 75.00 Hydrophthalmos 5 5.00 Targeted Disruption 3 5.00 Sprains And Strains 2 5.00 Optic Disorders 2 5.00 Hyperplasia 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Here we demonstrate that deficiency of Vav2 and Vav3, guanine nucleotides exchange factors for Rho guanosine triphosphatases, leads to an ocular phenotype similar to human glaucoma.

Positive_regulation (leads) of Negative_regulation (deficiency) of Vav2 associated with glaucoma

1) Confidence 0.50 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2816215 Disease Relevance 0.73 Pain Relevance 0

General Comments

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