INT294427

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.40
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Vegfa) extracellular space (Vegfa) growth (Vegfa)
extracellular region (Vegfa) cytoplasm (Vegfa)
Anatomy Link Frequency
retinas 2
colon 2
Vegfa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Parenteral administration 1 89.84 High High
corticosteroid 9 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Antihistamine 4 5.00 Very Low Very Low Very Low
peripheral neuropathy 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
induced neuropathy 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetic Macular Edema 21 99.56 Very High Very High Very High
Cancer 107 99.40 Very High Very High Very High
Solid Tumor 3 98.88 Very High Very High Very High
Colon Cancer 6 98.16 Very High Very High Very High
Diabetes Mellitus 55 96.76 Very High Very High Very High
Colorectal Cancer 18 92.92 High High
Breast Cancer 27 85.88 High High
Apoptosis 27 81.40 Quite High
Malignant Neoplastic Disease 2 77.36 Quite High
Toxicity 22 76.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies in vitro suggest that one mechanism for resistance to chemotherapy is the increased expression of vascular endothelial growth factor A (VEGF-A) that is primarily responsible for the vascularization of solid tumors.37,38 Paclitaxel, docetaxel,39 cisplatin,40 carboplatin,41 anthracyclines,42 fluorouracil43 can induce VEGF-A expression.
Regulation (responsible) of Gene_expression (expression) of VEGF-A associated with solid tumor
1) Confidence 0.44 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886338 Disease Relevance 0.64 Pain Relevance 0.04
To elucidate the mechanism of the unique beneficial effect of intravitreal steroid therapy on diabetic macular edema, we investigated the effect of locally administered triamcinolone acetonide (TA) on the expression of vascular endothelial growth factor (VEGF)-A and its receptors in retinas of rats with streptozotocin (STZ)-induced diabetes.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of vascular endothelial growth factor in retinas associated with diabetic macular edema and diabetes mellitus
2) Confidence 0.17 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2836241 Disease Relevance 0.47 Pain Relevance 0
Down-regulation of endothelial growth factor expression and thus inhibition of angiogenesis in human colon cancer can be achieved with wild type p53 gene transfer (23).
Regulation (regulation) of Gene_expression (expression) of endothelial growth factor in colon associated with colon cancer
3) Confidence 0.09 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 1.29 Pain Relevance 0

General Comments

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