INT294455

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (HIF1A) signal transduction (HIF1A) peptidase activity (KLK4)
extracellular region (KLK4) nucleolus (HIF1A) nucleus (HIF1A)
Anatomy Link Frequency
extracellular matrix 2
KLK4 (Homo sapiens)
HIF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 10 97.28 Very High Very High Very High
anesthesia 12 5.00 Very Low Very Low Very Low
fibrosis 12 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 4 28.32 Quite Low
Cancer 24 26.24 Quite Low
Chronic Hepatitis C 4 21.20 Low Low
Chronic Hepatitis 18 8.00 Low Low
Stress 24 5.00 Very Low Very Low Very Low
Injury 20 5.00 Very Low Very Low Very Low
INFLAMMATION 18 5.00 Very Low Very Low Very Low
Cirrhosis 16 5.00 Very Low Very Low Very Low
Hepatitis C Virus Infection 12 5.00 Very Low Very Low Very Low
Hypoxia 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The 23 up-regulated genes mainly encoded proteins involved in immune response (interferon pathway, growth factor, growth factor receptor, cytokine: IL8, CXCR4, CCL2, CXCL1, IL6, CCL3, CCL4, LIF, CXCL5, IL1A); and matrix remodeling (angiogenesis, extracellular matrix, extracellular matrix protease, inhibitors of matrix protease: PAI1, THBS1, PTGS2, HIF1A, MMP9, CTGF, HAS2, PAI2, MMP2, and COL1A1).
matrix protease Negative_regulation (inhibitors) of HIF1A in extracellular matrix associated with cytokine
1) Confidence 0.01 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0 Pain Relevance 0.05
The 23 up-regulated genes mainly encoded proteins involved in immune response (interferon pathway, growth factor, growth factor receptor, cytokine: IL8, CXCR4, CCL2, CXCL1, IL6, CCL3, CCL4, LIF, CXCL5, IL1A); and matrix remodeling (angiogenesis, extracellular matrix, extracellular matrix protease, inhibitors of matrix protease: PAI1, THBS1, PTGS2, HIF1A, MMP9, CTGF, HAS2, PAI2, MMP2, and COL1A1).
matrix protease Negative_regulation (inhibitors) of HIF1A in extracellular matrix associated with cytokine
2) Confidence 0.00 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0 Pain Relevance 0.05

General Comments

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