INT29446

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Context Info
Confidence 0.38
First Reported 1983
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 1.87
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Crh, POMC) extracellular space (Crh, POMC) extracellular region (Crh, POMC)
small molecule metabolic process (POMC) cell-cell signaling (POMC) response to stress (Crh)
Anatomy Link Frequency
plasma 2
pars distalis 2
gland 2
anterior pituitary 2
Crh (Rattus norvegicus)
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 6 100.00 Very High Very High Very High
dexamethasone 5 98.68 Very High Very High Very High
electroacupuncture 136 98.16 Very High Very High Very High
antagonist 12 96.68 Very High Very High Very High
Central nervous system 20 96.08 Very High Very High Very High
opiate 2 95.88 Very High Very High Very High
Enkephalin 1 91.56 High High
Inflammation 92 89.72 High High
Morphine 6 86.80 High High
midbrain 1 82.08 Quite High
Disease Link Frequency Relevance Heat
Stress 23 98.76 Very High Very High Very High
Pituitary Cancer 1 97.68 Very High Very High Very High
Autoimmune Disease 4 90.64 High High
INFLAMMATION 97 89.72 High High
Urological Neuroanatomy 8 81.36 Quite High
Disease 31 77.12 Quite High
Fever 1 75.16 Quite High
Depression 1 73.84 Quite High
Pressure And Volume Under Development 24 73.20 Quite High
Adhesions 1 68.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The secreted CRH acted on CRH receptors to increase ACTH release, which is supported by the data showing that EA significantly increases plasma ACTH levels in CFA-inflamed rats compared to sham EA.
CRH Positive_regulation (increase) of Localization (release) of ACTH in plasma associated with electroacupuncture
1) Confidence 0.38 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2408560 Disease Relevance 0.49 Pain Relevance 0.89
The present studies were designed to investigate whether the central action of AII on ACTH release is directly mediated through CRF.
CRF Spec (whether) Positive_regulation (mediated) of Localization (release) of ACTH
2) Confidence 0.26 Published 1986 Journal Endocrinology Section Abstract Doc Link 3015575 Disease Relevance 0 Pain Relevance 0.13
CRF stimulated the release of opioid beta-endorphin from the pars distalis.
CRF Positive_regulation (stimulated) of Localization (release) of beta-endorphin in pars distalis associated with opioid
3) Confidence 0.22 Published 2001 Journal J. Endocrinol. Section Abstract Doc Link 11312144 Disease Relevance 0 Pain Relevance 0.10
In vitro: In a continuous perfusion system of isolated anterior pituitary cells from rats or human anterior pituitary adenoma, producing ACTH, ketoconazole 10(-5)-10(-6) M showed no inhibitory effects on both basal or lisine-vasopressin and oCRH stimulated ACTH secretion.
oCRH Neg (no) Positive_regulation (stimulated) of Localization (secretion) of ACTH in anterior pituitary associated with pituitary cancer
4) Confidence 0.21 Published 1987 Journal Horm. Metab. Res. Suppl. Section Abstract Doc Link 2832292 Disease Relevance 0.32 Pain Relevance 0.07
Under the same conditions, CRF and AVP stimulated ACTH release to a greater degree at 10(-10) and 10(-9) M, respectively.
CRF Positive_regulation (stimulated) of Localization (release) of ACTH
5) Confidence 0.17 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6318148 Disease Relevance 0 Pain Relevance 0.15
CRH then stimulates the expression and release of adrenocorticotropin (ACTH) from the anterior pituitary gland.
CRH Positive_regulation (stimulates) of Localization (release) of ACTH in gland
6) Confidence 0.08 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC333413 Disease Relevance 0.53 Pain Relevance 0.49
It is concluded that CRF stimulates a rapid increase in the secretion of ACTH and beta LPH in sheep.
CRF Positive_regulation (stimulates) of Localization (secretion) of ACTH
7) Confidence 0.04 Published 1983 Journal Endocrinology Section Abstract Doc Link 6307669 Disease Relevance 0 Pain Relevance 0.22
By stimulating the release of adrenocorticotropin hormone (ACTH), CRF acts as a key mediator of the stress response.
CRF Positive_regulation (stimulating) of Localization (release) of ACTH associated with stress
8) Confidence 0.04 Published 2003 Journal Brain Res. Section Abstract Doc Link 12885425 Disease Relevance 0.53 Pain Relevance 0.25
Furthermore, blockade of CRF-induced beta-endorphin or ACTH release into the general circulation by dexamethasone did not interfere with the inhibitory effect of CRF on LH secretion.
CRF Positive_regulation (induced) of Localization (release) of ACTH associated with dexamethasone
9) Confidence 0.03 Published 1984 Journal Endocrinology Section Abstract Doc Link 6321146 Disease Relevance 0 Pain Relevance 0.27

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