INT294469

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Context Info
Confidence 0.66
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.46
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (THBS1) extracellular region (THBS1) cell adhesion (THBS1)
structural molecule activity (THBS1)
THBS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 8 68.88 Quite High
fibrosis 6 38.72 Quite Low
Inflammation 9 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Gabapentin 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 13 94.08 High High
Cancer 57 93.20 High High
Malignant Neoplastic Disease 2 77.28 Quite High
Chronic Hepatitis C 2 70.16 Quite High
Chronic Hepatitis 9 51.60 Quite High
Cirrhosis 8 39.20 Quite Low
Hepatitis C Virus Infection 6 29.60 Quite Low
Infection 5 10.00 Low Low
Stress 12 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Up-regulation of TSP1 mRNA by E2F1 was confirmed by Northern blot analysis (Fig. 4) which suggested that E2F1 could indeed induce TSP1 mRNA expression.


Transcription (expression) of TSP1
1) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
In this study, we show that E2F-1 could activate the transcription of TSP1 by both promoter assays and Northern blot.
Transcription (transcription) of TSP1
2) Confidence 0.66 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955548 Disease Relevance 0.19 Pain Relevance 0
E2F1 up-regulates TSP1 mRNA expression
Transcription (expression) of TSP1
3) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
Fig. 3 shows the mRNA levels of three of these genes (PAI1, THBS1, and IHH) in each of the 14 group B samples and the 14 group A samples.
Transcription (levels) of THBS1
4) Confidence 0.43 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.27 Pain Relevance 0.03

General Comments

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