INT294474

Context Info Confidence 0.25 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.87 Pain Relevance 0.29

Anatomy Link Frequency extracellular matrix 2 HAS2 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 10 97.22 alcohol 4 68.32 anesthesia 12 62.24 Inflammation 12 24.88 fibrosis 12 5.00 Inflammatory response 6 5.00 ischemia 4 5.00 chemokine 4 5.00 Bile 2 5.00 tolerance 2 5.00

Disease Link Frequency Relevance Heat Cancer 24 92.40 Malignant Neoplastic Disease 4 80.24 Liver Cancer 4 76.92 Colon Cancer 4 76.00 Benign Tumor 2 75.36 Metastasis 8 75.16 Acute-phase Reaction 12 71.44 Metabolic Disorder 4 71.12 Hepatitis Virus Infection 4 69.32 Stress 24 66.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The 26 genes that were significantly dysregulated (23 up-regulated and three down-regulated) in the group B samples mainly encoded proteins involved in immune response (interferon pathway, growth factor, growth factor receptor, cytokine: IL8, CXCR4, CCL2, CXCL1, IL6, CCL3, CCL4, LIF) and matrix remodeling (angiogenesis, extracellular matrix, extracellular matrix protease, inhibitors of matrix protease: PAI1, THBS1, PTGS2, HIF1A, MMP9, CTGF, HAS2, PAI2, and MMP2).

Negative_regulation (inhibitors) of HAS2 in extracellular matrix associated with cytokine

1) Confidence 0.25 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.94 Pain Relevance 0.15

The 26 genes that were significantly dysregulated (23 up-regulated and three down-regulated) in the group B samples mainly encoded proteins involved in immune response (interferon pathway, growth factor, growth factor receptor, cytokine: IL8, CXCR4, CCL2, CXCL1, IL6, CCL3, CCL4, LIF) and matrix remodeling (angiogenesis, extracellular matrix, extracellular matrix protease, inhibitors of matrix protease: PAI1, THBS1, PTGS2, HIF1A, MMP9, CTGF, HAS2, PAI2, and MMP2).

Negative_regulation (inhibitors) of HAS2 in extracellular matrix associated with cytokine

2) Confidence 0.09 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.94 Pain Relevance 0.15

General Comments

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