INT294476

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.86
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CTGF) Golgi apparatus (CTGF) cytosol (CTGF)
extracellular space (CTGF) extracellular region (CTGF) proteinaceous extracellular matrix (CTGF)
Anatomy Link Frequency
extracellular matrix 2
CTGF (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 10 97.22 Very High Very High Very High
alcohol 4 68.32 Quite High
anesthesia 12 62.24 Quite High
Inflammation 12 24.40 Low Low
fibrosis 12 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 24 91.92 High High
Malignant Neoplastic Disease 4 79.76 Quite High
Liver Cancer 4 76.92 Quite High
Colon Cancer 4 76.00 Quite High
Metastasis 8 75.16 Quite High
Benign Tumor 2 74.88 Quite High
Metabolic Disorder 4 71.12 Quite High
Acute-phase Reaction 12 70.96 Quite High
Hepatitis Virus Infection 4 69.32 Quite High
Liver Disease 6 66.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The 26 genes that were significantly dysregulated (23 up-regulated and three down-regulated) in the group B samples mainly encoded proteins involved in immune response (interferon pathway, growth factor, growth factor receptor, cytokine: IL8, CXCR4, CCL2, CXCL1, IL6, CCL3, CCL4, LIF) and matrix remodeling (angiogenesis, extracellular matrix, extracellular matrix protease, inhibitors of matrix protease: PAI1, THBS1, PTGS2, HIF1A, MMP9, CTGF, HAS2, PAI2, and MMP2).
Negative_regulation (inhibitors) of CTGF in extracellular matrix associated with cytokine
1) Confidence 0.27 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.93 Pain Relevance 0.15
The 26 genes that were significantly dysregulated (23 up-regulated and three down-regulated) in the group B samples mainly encoded proteins involved in immune response (interferon pathway, growth factor, growth factor receptor, cytokine: IL8, CXCR4, CCL2, CXCL1, IL6, CCL3, CCL4, LIF) and matrix remodeling (angiogenesis, extracellular matrix, extracellular matrix protease, inhibitors of matrix protease: PAI1, THBS1, PTGS2, HIF1A, MMP9, CTGF, HAS2, PAI2, and MMP2).
Negative_regulation (inhibitors) of CTGF in extracellular matrix associated with cytokine
2) Confidence 0.09 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.93 Pain Relevance 0.15

General Comments

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