INT294504

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 2010
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 0.97
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

growth (Safb) RNA binding (Safb) nucleus (Safb)
DNA binding (Safb)
Anatomy Link Frequency
myotubes 7
brain 1
synapses 1
Safb (Mus musculus)
Safb - R163C (2)
Pain Link Frequency Relevance Heat
amygdala 102 100.00 Very High Very High Very High
GABAergic 32 100.00 Very High Very High Very High
addiction 93 99.30 Very High Very High Very High
agonist 35 88.84 High High
gABA 48 85.28 High High
halothane 16 83.16 Quite High
cytokine 20 82.40 Quite High
withdrawal 11 74.56 Quite High
Inflammation 4 42.80 Quite Low
alcohol 24 31.20 Quite Low
Disease Link Frequency Relevance Heat
Contracture 14 84.00 Quite High
Malignant Hyperthermia 105 76.20 Quite High
Necrosis 2 73.96 Quite High
Cancer 2 73.60 Quite High
Anxiety Disorder 10 60.20 Quite High
INFLAMMATION 4 42.80 Quite Low
Recurrence 2 29.36 Quite Low
Stress 4 28.36 Quite Low
Alcohol Addiction 16 24.00 Low Low
Immunization 26 17.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
secretion was observed by oral administration of HET (Fig. 4A–C).
Gene_expression (administration) of HET
1) Confidence 0.41 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816392 Disease Relevance 0.15 Pain Relevance 0.12
In contrast, Ca2+ transients in response to whole cell depolarization were reduced either somewhat in R163C Het myotubes or substantially in R163C Hom myotubes (Fig. 1), which could be at least partially attributed to reduced membrane expression of the DHPR (Fig. 2).
Gene_expression (myotubes) of Het (R163C) in myotubes
2) Confidence 0.20 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888063 Disease Relevance 0 Pain Relevance 0
In order to analyze the effect of HET on IgA immune response against intestinal antigen, HET was administered to mice at a dose of 1000 mg kg?
Spec (analyze) Gene_expression (response) of HET
3) Confidence 0.18 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816392 Disease Relevance 0 Pain Relevance 0
In contrast, the potentiation of L-type currents by ±Bay K 8644 (10 µM) was appreciable in Het myotubes (Fig. 4 B), and even larger in Hom myotubes (Fig. 4 C).
Gene_expression (myotubes) of Het in myotubes
4) Confidence 0.17 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888063 Disease Relevance 0.08 Pain Relevance 0.12
5-mV hyperpolarizing shifts in the voltage dependence of Ca2+ release for R163C Hom and Het myotubes (Table I), we also observed an ?
Gene_expression (myotubes) of Het in myotubes associated with addiction
5) Confidence 0.17 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888063 Disease Relevance 0.13 Pain Relevance 0.11
The current–voltage relationships for L-type currents in both Hom and Het myotubes were also shifted to more hyperpolarizing potentials (?
Gene_expression (myotubes) of Het in myotubes
6) Confidence 0.17 Published 2010 Journal The Journal of General Physiology Section Abstract Doc Link PMC2888063 Disease Relevance 0.29 Pain Relevance 0.04
10 mV in the hyperpolarizing direction for both Het and Hom myotubes (V1/2 = ?
Gene_expression (myotubes) of Het in myotubes
7) Confidence 0.17 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888063 Disease Relevance 0.07 Pain Relevance 0.06
In R163C Het myotubes, there was a small hyperpolarizing shift in SR Ca2+ release and a slight reduction in maximal release ([?
Gene_expression (myotubes) of Het (R163C) in myotubes
8) Confidence 0.17 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888063 Disease Relevance 0.05 Pain Relevance 0.18
12 mV) in Het myotubes (Fig. 2 and Table II).
Gene_expression (myotubes) of Het in myotubes
9) Confidence 0.17 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888063 Disease Relevance 0.13 Pain Relevance 0.07
Using Affymetrix gene expression arrays, we previously demonstrated that the only protein coding mRNA which was altered (diminished) in the brain of male HET mice was the ADCY7 product (Hines et al., 2006).
Gene_expression (product) of HET in brain
10) Confidence 0.15 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.06 Pain Relevance 0.45
Therefore, using an in vitro electrophysiological approach in brain slices, here we have investigated a possible role of the AC7 signaling pathway in ethanol and CRF effects on CeA GABAergic synapses of genetically modified mice with diminished brain Adcy7 activity (HET) compared to their littermate male wild-type (WT) mice.
Gene_expression (effects) of HET in synapses associated with gabaergic and amygdala
11) Confidence 0.15 Published 2011 Journal Frontiers in Neuroscience Section Abstract Doc Link PMC3024005 Disease Relevance 0 Pain Relevance 0.57

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox