INT294583

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.01
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

immune system process (Ahr) cell morphogenesis (Ahr) DNA binding (Ahr)
response to stress (Ahr) cytoplasm (Ahr) signal transducer activity (Ahr)
Anatomy Link Frequency
lung 2
Ahr (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 45 74.64 Quite High
chemokine 6 74.08 Quite High
Inflammation 32 66.64 Quite High
fibrosis 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Neuritis 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prostate Cancer 56 98.52 Very High Very High Very High
Asthma 104 71.72 Quite High
Targeted Disruption 9 70.08 Quite High
INFLAMMATION 33 66.64 Quite High
Apoptosis 2 63.32 Quite High
Stress 4 61.60 Quite High
Hyperplasia 4 60.72 Quite High
Frailty 6 59.68 Quite High
Disease Progression 1 50.40 Quite High
Recurrence 5 46.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our study, knocking down the AhR per se in LNCaP cells did not alter prostate cancer cell growth (Figure 5A), suggesting that the basal levels of AhR do not exert an inhibitory effect unless stimulated by ligand.
Negative_regulation (down) of Gene_expression (knocking) of AhR associated with prostate cancer
1) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 0.68 Pain Relevance 0.03
In that study, analysis of the murine IL-9 gene identified a genetic defect at the C57BL/6(B6)IL-9 locus associated with a lack of IL-9 expression in the lung and reduced AHR in naive B6 mice.
Negative_regulation (lack) of Gene_expression (expression) of AHR in lung
2) Confidence 0.17 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.33 Pain Relevance 0.11

General Comments

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