INT294604

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Context Info
Confidence 0.16
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.02
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Serpinh1) endoplasmic reticulum (Serpinh1) protein maturation (Serpinh1)
response to stress (Serpinh1) cytoplasm (Serpinh1)
Serpinh1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 14 67.04 Quite High
Inflammation 20 66.68 Quite High
cytokine 12 59.84 Quite High
tolerance 16 5.00 Very Low Very Low Very Low
anesthesia 12 5.00 Very Low Very Low Very Low
ketamine 8 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 14 99.92 Very High Very High Very High
Stomach Cancer 116 95.24 Very High Very High Very High
Shock 60 92.76 High High
Cancer 126 90.96 High High
Malignant Neoplastic Disease 20 85.68 High High
Apoptosis 4 83.84 Quite High
Stress 60 81.12 Quite High
Cataract 80 75.68 Quite High
Cervical Cancer 4 71.12 Quite High
INFLAMMATION 22 66.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SERPINH1 (HSP47) was also associated with metastatic disease and had been shown earlier to be a marker for metastatic tumour cells [34].
HSP47 Binding (associated) of associated with metastasis
1) Confidence 0.16 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.25 Pain Relevance 0.06
SERPINH1 (HSP47) was also associated with metastatic disease and had been shown earlier to be a marker for metastatic tumour cells [34].
SERPINH1 Binding (associated) of associated with metastasis
2) Confidence 0.16 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.25 Pain Relevance 0.06
In addition, Hsp 47 is reported to be associated as a molecular chaperone with ?
Hsp 47 Binding (associated) of
3) Confidence 0.09 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.32 Pain Relevance 0.05
Hsp 47 has been reported to bind to type I-V collagen in vitro (38), and its expression has been shown to be correlated with both types I and III collagen in vivo (39).
Hsp 47 Binding (bind) of
4) Confidence 0.09 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.44 Pain Relevance 0.09
Hsp 47 has been reported to be associated with the metabolism or processing of procollagen as a molecular chaperone specific to collagen (17), and is believed to play an important role in development because collagen biosynthesis is one of the major molecular events driving embryogenesis.
Hsp 47 Binding (associated) of
5) Confidence 0.09 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.27 Pain Relevance 0
Although most molecular chaperones characterized to date have been shown to bind non-selectively to denatured or immature proteins, Hsp 47 is a 'specific chaperone' for collagen in terms of its binding specificity (17, 33-37).
Hsp 47 Binding (bind) of
6) Confidence 0.09 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.47 Pain Relevance 0.10

General Comments

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