INT294681

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.27
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Tlr4, NFKB1) signal transduction (Tlr4, NFKB1) nucleoplasm (NFKB1)
mitochondrion (NFKB1) intracellular (Tlr4) cytosol (NFKB1)
Anatomy Link Frequency
T lymphocytes 2
Tlr4 (Mus musculus)
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 5 98.28 Very High Very High Very High
agonist 2 57.44 Quite High
Inflammation 9 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fungal Infection 1 90.40 High High
Bacterial Infection 1 66.56 Quite High
Sprains And Strains 4 63.56 Quite High
Shock 3 50.16 Quite High
Fever 2 49.76 Quite Low
Infection 9 44.08 Quite Low
General Immunology 1 22.64 Low Low
Amebic Liver Abscess 10 17.48 Low Low
Amebiasis 22 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, it was found that a constitutively active mutant of human TLR4, transfected into a monocytic cell line, could induce the activation of NF-kappaB and the expression of the proinflammatory cytokines IL-1, IL-6, and IL-8 as well as the expression of the costimulatory molecule CD80 (B7.1), which is required for the activation of naïve T lymphocytes [66].
TLR4 Positive_regulation (induce) of Positive_regulation (activation) of NF-kappaB in T lymphocytes associated with cytokine
1) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817369 Disease Relevance 0.27 Pain Relevance 0.10

General Comments

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