INT2947

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Context Info
Confidence 0.44
First Reported 1979
Last Reported 2009
Negated 3
Speculated 5
Reported most in Abstract
Documents 10
Total Number 15
Disease Relevance 5.81
Pain Relevance 4.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TFPI) extracellular region (TFPI) plasma membrane (TFPI)
Anatomy Link Frequency
EPI 4
plasma 2
blood 1
spinal 1
CSF 1
TFPI (Homo sapiens)
Pain Link Frequency Relevance Heat
analgesia 17 100.00 Very High Very High Very High
epidural 15 100.00 Very High Very High Very High
Inflammation 10 99.88 Very High Very High Very High
aspirin 84 99.84 Very High Very High Very High
withdrawal 4 99.76 Very High Very High Very High
Angina 13 99.72 Very High Very High Very High
Pain 6 98.58 Very High Very High Very High
intrathecal 4 98.00 Very High Very High Very High
Clonidine 8 97.56 Very High Very High Very High
Opioid 2 97.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 14 99.88 Very High Very High Very High
Cv General 3 Under Development 60 99.72 Very High Very High Very High
Pain 6 98.58 Very High Very High Very High
Sepsis 51 98.20 Very High Very High Very High
Congenital Anomalies 2 98.16 Very High Very High Very High
Heart Disease 19 98.12 Very High Very High Very High
Coagulation Disorder 8 97.54 Very High Very High Very High
Fever 11 91.12 High High
Increased Venous Pressure Under Development 4 87.00 High High
Pancreatitis 3 86.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: This study was designed to evaluate the plasma levels of tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in patients with unstable angina and investigate whether there is a relationship between these levels and unfavorable outcome.
Spec (investigate) Regulation (evaluate) of TFPI in plasma associated with angina
1) Confidence 0.44 Published 1999 Journal Circulation Section Abstract Doc Link 10359735 Disease Relevance 0.17 Pain Relevance 0.17
The three major anticoagulant mechanisms appear to involve antithrombin-heparin, Tissue Factor pathway inhibitor (TFPI) and the Protein C pathway.
Regulation (involve) of TFPI
2) Confidence 0.44 Published 1999 Journal Baillieres Best Pract. Res. Clin. Haematol. Section Abstract Doc Link 10856974 Disease Relevance 0.65 Pain Relevance 0.35
The kinetics of FVIIa and F1+2 inhibition did not follow those of anti-Xa activity and TFPI release.
Neg (not) Regulation (follow) of TFPI
3) Confidence 0.44 Published 2003 Journal Br. J. Haematol. Section Abstract Doc Link 12588347 Disease Relevance 0.13 Pain Relevance 0.13
BACKGROUND: This study was designed to evaluate the plasma levels of tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in patients with unstable angina and investigate whether there is a relationship between these levels and unfavorable outcome.
Spec (investigate) Regulation (evaluate) of pathway inhibitor in plasma associated with angina
4) Confidence 0.39 Published 1999 Journal Circulation Section Abstract Doc Link 10359735 Disease Relevance 0.17 Pain Relevance 0.17
To determine if the same mechanism is responsible for the EPI-induced ?
Spec (determine) Regulation (responsible) of EPI-induced in EPI
5) Confidence 0.17 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0.14
2AR4 cells, it is not known whether GRK3 recruitment to the membrane is regulated via chronic EPI treatment in that cell line.
Spec (whether) Regulation (regulated) of EPI in EPI
6) Confidence 0.17 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0.04
The three major anticoagulant mechanisms appear to involve antithrombin-heparin, Tissue Factor pathway inhibitor (TFPI) and the Protein C pathway.
Regulation (involve) of Tissue Factor pathway inhibitor
7) Confidence 0.17 Published 1999 Journal Baillieres Best Pract. Res. Clin. Haematol. Section Abstract Doc Link 10856974 Disease Relevance 0.65 Pain Relevance 0.35
There was little evidence that IPTi per se had a negative impact on attitudes to EPI or that it had any affect on EPI adherence.
Regulation (affect) of EPI in EPI
8) Confidence 0.13 Published 2009 Journal Malar J Section Abstract Doc Link PMC2734860 Disease Relevance 0.24 Pain Relevance 0
Serial changes in angiotensin II, epi- and norepinephrine as well as thromboxane B2 (the stable derivate of thromboxane A2), and malondialdehyde were determined at baseline (I), immediately after 5 minutes cold water hand immersion (II), and following 10 minutes recovery (III).
Regulation (changes) of epi
9) Confidence 0.12 Published 1989 Journal Int. J. Cardiol. Section Abstract Doc Link 2807608 Disease Relevance 0.36 Pain Relevance 0.10
However, aspirin had no effect in either EPI-COLL or ADP-COLL in patients with STEMI (Fig 2).
Neg (no) Regulation (effect) of EPI-COLL in EPI associated with aspirin
10) Confidence 0.06 Published 2005 Journal Thromb J Section Body Doc Link PMC1192820 Disease Relevance 0.73 Pain Relevance 0.22
CSF EPI was not affected by either treatment.
Neg (not) Regulation (affected) of EPI in CSF
11) Confidence 0.03 Published 1987 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2455180 Disease Relevance 0.39 Pain Relevance 0.82
Combined spinal-epidural (CSE) and intrathecal analgesia (ITA) techniques have been used to provide pain relief for parturients, but currently there are few studies comparing EPI, CSE, and ITA techniques and their effect on the length of labor.
Regulation (effect) of EPI in spinal associated with pain, epidural, analgesia and intrathecal
12) Confidence 0.01 Published 1998 Journal CRNA Section Abstract Doc Link 9866483 Disease Relevance 0.19 Pain Relevance 1.74
The effects of Isoptin i) on isolated microtubules, ii) on the anti-immunoglobulin and the Concanavalin A induced changes in the plasma membrane topography of murine lymphocytes and iii) on murine lymphocyte activation by lipopolysaccharide and by Concanavalin A was investigated.
Spec (investigated) Regulation (effects) of anti-immunoglobulin in lymphocyte
13) Confidence 0.00 Published 1979 Journal Z Immunitatsforsch Immunobiol Section Abstract Doc Link 572609 Disease Relevance 0 Pain Relevance 0.15
The data suggest that there is local activation of blood coagulation in pancreatic tissue in chronic inflammation that depends on tissue factor.
Regulation (depends) of tissue factor in blood associated with inflammation
14) Confidence 0.00 Published 1998 Journal Pol. Merkur. Lekarski Section Abstract Doc Link 10101456 Disease Relevance 0.65 Pain Relevance 0.40
The contribution of coagulopathy to the pathophysiology of sepsis has become more widely understood [4-7] and has increased the interest in compounds that modulate the coagulation cascade such as antithrombin, tissue factor pathway inhibitor, and activated protein C [8-10].
Regulation (modulate) of tissue factor pathway associated with coagulation disorder and sepsis
15) Confidence 0.00 Published 2005 Journal Crit Care Section Body Doc Link PMC1269439 Disease Relevance 1.47 Pain Relevance 0.08

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