INT294709

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.14
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (IRF6, CCL2) aging (CCL2) DNA binding (IRF6)
cytosol (IRF6) extracellular space (CCL2) signal transduction (CCL2)
Anatomy Link Frequency
blood 2
IRF6 (Homo sapiens)
CCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 60 93.24 High High
Inflammation 36 71.68 Quite High
alcohol 4 6.48 Low Low
chemokine 4 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 40 71.68 Quite High
Increased Venous Pressure Under Development 12 5.00 Very Low Very Low Very Low
Adhesions 8 5.00 Very Low Very Low Very Low
Coronary Artery Disease 6 5.00 Very Low Very Low Very Low
Hyperhomocysteinemia 4 5.00 Very Low Very Low Very Low
Atherosclerotic Plaque 2 5.00 Very Low Very Low Very Low
Bacterial Infection 2 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LPS and recombinant CRP increased IL-6 (Figure 1a) and MCP-1 (Figure 1b) production significantly (all P values < 0.001 compared to saline control).
LPS Positive_regulation (increased) of Gene_expression (production) of MCP-1
1) Confidence 0.08 Published 2008 Journal Archives of Drug Information Section Body Doc Link PMC2817441 Disease Relevance 0 Pain Relevance 0.08
Both human recombinant CRP and LPS significantly increased the production of IL-6 and MCP-1 in whole blood samples more than 4-fold (P < 0.001) but homocysteine did not.
LPS Positive_regulation (increased) of Gene_expression (production) of MCP-1 in blood
2) Confidence 0.07 Published 2008 Journal Archives of Drug Information Section Abstract Doc Link PMC2817441 Disease Relevance 0.14 Pain Relevance 0.19

General Comments

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