INT294710

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.63
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.90
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRP, IL6) extracellular region (CRP, IL6) aging (IL6)
Anatomy Link Frequency
blood 8
CRP (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 150 100.00 Very High Very High Very High
Inflammation 90 100.00 Very High Very High Very High
Angina 5 91.52 High High
Bioavailability 5 23.56 Low Low
chemokine 10 5.00 Very Low Very Low Very Low
alcohol 10 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 100 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 30 96.88 Very High Very High Very High
Cv General 3 Under Development 5 91.52 High High
Adhesions 20 82.52 Quite High
Bacterial Infection 5 79.76 Quite High
Atherosclerotic Plaque 5 72.20 Quite High
Hyperhomocysteinemia 10 48.96 Quite Low
Coronary Artery Disease 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus our studies suggest that human recombinant CRP in the presence of very low levels of endotoxin stimulates IL-6 and MCP-1 production in whole blood.
CRP Positive_regulation (stimulates) of Gene_expression (production) of IL-6 in blood
1) Confidence 0.63 Published 2008 Journal Archives of Drug Information Section Body Doc Link PMC2817441 Disease Relevance 0.51 Pain Relevance 0.25
In summary, human recombinant CRP with low concentrations of endotoxin stimulated the production of the proatherogenic mediators MCP-1 and IL-6 in human whole blood, but homocysteine did not.
CRP Positive_regulation (stimulated) of Gene_expression (production) of IL-6 in blood
2) Confidence 0.63 Published 2008 Journal Archives of Drug Information Section Body Doc Link PMC2817441 Disease Relevance 0.15 Pain Relevance 0.15
We found that recombinant CRP markedly increased the production of IL-6 and MCP-1, cytokines that are thought to be important in the pathogenesis of atherosclerosis [25,26].
CRP Positive_regulation (increased) of Gene_expression (production) of IL-6 associated with increased venous pressure under development and cytokine
3) Confidence 0.42 Published 2008 Journal Archives of Drug Information Section Body Doc Link PMC2817441 Disease Relevance 0.77 Pain Relevance 0.36
CRP stimulated the production of the proatherogenic mediators MCP-1 and IL-6 in human whole blood, but homocysteine did not.
CRP Positive_regulation (stimulated) of Gene_expression (production) of IL-6 in blood
4) Confidence 0.42 Published 2008 Journal Archives of Drug Information Section Abstract Doc Link PMC2817441 Disease Relevance 0.10 Pain Relevance 0.16
We found that human recombinant CRP stimulated production of the inflammatory cytokines IL-6 and MCP-1 in whole blood but that homocysteine did not.
CRP Positive_regulation (stimulated) of Gene_expression (production) of IL-6 in blood associated with inflammation and cytokine
5) Confidence 0.42 Published 2008 Journal Archives of Drug Information Section Body Doc Link PMC2817441 Disease Relevance 0.36 Pain Relevance 0.19

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox