INT294751

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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 2.52
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cerk) nucleus (Cerk) kinase activity (Cerk)
cytoplasm (Cerk)
Anatomy Link Frequency
macrophages 1
Cerk (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 105 99.56 Very High Very High Very High
Inflammation 56 89.44 High High
fibrosis 7 86.68 High High
anesthesia 7 5.00 Very Low Very Low Very Low
isoflurane 7 5.00 Very Low Very Low Very Low
Arthritis 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 21 99.96 Very High Very High Very High
Disease 28 98.68 Very High Very High Very High
INFLAMMATION 56 89.44 High High
Asthma 56 86.72 High High
Fibrosis 7 86.68 High High
Apoptosis 7 86.40 High High
Hypersensitivity 7 53.44 Quite High
Anaphylactic Hypersensitivity 7 53.04 Quite High
Anaphylaxis 14 24.56 Low Low
Sprains And Strains 28 21.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, even if this did not reach statistical significance, the same experiments also revealed that IL-13 and IL-5 levels are reduced in absence of CERK (Fig. 1).
Negative_regulation (absence) of CERK
1) Confidence 0.43 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.32 Pain Relevance 0.15
In fact, the dynamic (as opposed to "established" i.e. in KO animals) down-regulation of CERK might represent a negative feedback mechanism.
Negative_regulation (regulation) of CERK
2) Confidence 0.43 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.75 Pain Relevance 0.12
can inhibit CERK at mRNA levels in primary macrophages (P.
Negative_regulation (inhibit) of CERK in macrophages
3) Confidence 0.43 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.15 Pain Relevance 0.12
Of note, however, neither knocking down the Cerk gene [3] nor using a CERK inhibitor [10] could recapitulate these findings, which suggests compensation by other C1P pools that do not depend on CERK for their synthesis.
Negative_regulation (inhibitor) of CERK
4) Confidence 0.43 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.16 Pain Relevance 0
During this fulminant infection, absence of CERK led to drastic worsening of the disease resulting in early mortality.
Negative_regulation (absence) of CERK associated with disease and infection
5) Confidence 0.43 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.82 Pain Relevance 0.08
IL-4 and IL-13; levels of the latter are only partially reduced in absence of CERK; Fig. 1).
Negative_regulation (absence) of CERK
6) Confidence 0.43 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.17 Pain Relevance 0.12
Of note, however, neither knocking down the Cerk gene [3] nor using a CERK inhibitor [10] could recapitulate these findings, which suggests compensation by other C1P pools that do not depend on CERK for their synthesis.
Neg (nor) Negative_regulation (knocking) of Cerk
7) Confidence 0.43 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.15 Pain Relevance 0

General Comments

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