INT294755

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.23
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cerk) nucleus (Cerk) kinase activity (Cerk)
cytoplasm (Cerk)
Cerk (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 60 91.60 High High
Inflammation 32 89.44 High High
fibrosis 4 65.12 Quite High
Arthritis 4 7.44 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 16 99.12 Very High Very High Very High
Infection 12 96.92 Very High Very High Very High
Asthma 32 91.32 High High
INFLAMMATION 32 89.44 High High
Apoptosis 4 86.40 High High
Fibrosis 4 65.12 Quite High
Anaphylaxis 8 37.84 Quite Low
Hypersensitivity 4 13.52 Low Low
Anaphylactic Hypersensitivity 4 13.12 Low Low
Arthritis 4 7.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of note, however, neither knocking down the Cerk gene [3] nor using a CERK inhibitor [10] could recapitulate these findings, which suggests compensation by other C1P pools that do not depend on CERK for their synthesis.
Neg (nor) Regulation (using) of CERK
1) Confidence 0.45 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.15 Pain Relevance 0
In fact, the dynamic (as opposed to "established" i.e. in KO animals) down-regulation of CERK might represent a negative feedback mechanism.
Regulation (regulation) of CERK
2) Confidence 0.45 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.75 Pain Relevance 0.12
The physiological role of CERK and its relevance to disease is only starting to be addressed.
Regulation (role) of CERK associated with disease
3) Confidence 0.27 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.16 Pain Relevance 0
Altogether, despite a clear cut influence on IL-4 levels, to what extent CERK may participate in TH2 cell biology remains elusive.
Spec (may) Regulation (participate) of CERK
4) Confidence 0.27 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.16 Pain Relevance 0.12

General Comments

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