INT294775

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.04
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (IRF6, TLR4) cytosol (IRF6) signal transduction (TLR4)
plasma membrane (TLR4) intracellular (TLR4) nucleus (IRF6)
Anatomy Link Frequency
monocytes 3
alveolar macrophages 2
leukocyte 1
MD2 1
IRF6 (Homo sapiens)
TLR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 108 100.00 Very High Very High Very High
chemokine 30 98.32 Very High Very High Very High
cytokine 214 97.76 Very High Very High Very High
Inflammation 162 91.88 High High
Inflammatory response 35 88.52 High High
Inflammatory mediators 6 79.64 Quite High
tolerance 14 67.20 Quite High
ischemia 8 53.76 Quite High
Bile 10 42.28 Quite Low
fibrosis 36 19.04 Low Low
Disease Link Frequency Relevance Heat
Mycobacterial Infection 135 100.00 Very High Very High Very High
INFLAMMATION 195 91.88 High High
Infection 34 69.60 Quite High
Hepatitis C Virus Infection 20 68.88 Quite High
Hepatitis 10 62.32 Quite High
Targeted Disruption 2 60.32 Quite High
Reperfusion Injury 22 54.72 Quite High
Cirrhosis 122 54.24 Quite High
Cv Unclassified Under Development 6 53.76 Quite High
Stress 18 51.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LPS stimulates TLR4 on KCs to enhance hepatocyte damage, increase leukocyte infiltration and secrete pro-fibrogenic cytokines.
LPS Positive_regulation (stimulates) of TLR4 in leukocyte associated with agonist and cytokine
1) Confidence 0.08 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.11 Pain Relevance 0.86
Activation of TLR4 by LPS absolutely requires the presence of the co-receptor MD2 for signaling, whereas some TLR4-mediated signals may still be generated in the absence of CD14.
LPS Positive_regulation (Activation) of TLR4 in MD2
2) Confidence 0.06 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0 Pain Relevance 0
LPS upregulated TLR4 mRNA in both monocytes and alveolar macrophages after 1 h only, and was decreased below basal levels in both cells types after 24 h (Figure 5B).
LPS Positive_regulation (upregulated) of TLR4 in alveolar macrophages
3) Confidence 0.06 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.38 Pain Relevance 0.03
Pam3Cys, LPS, and M.tb DNA upregulated TLR2, TLR4 and TLR9 mRNA in both, bronchoalveolar cells and monocytes.
LPS Positive_regulation (upregulated) of TLR4 in monocytes associated with mycobacterial infection
4) Confidence 0.06 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2817655 Disease Relevance 0.17 Pain Relevance 0.10
TLR4, in contrast was shown to be upregulated in response to LPS on monocytes and alveolar macrophages in a kinetic similar to that of TLR2 using both flow cytometry and qRT-PCR.
LPS Positive_regulation (upregulated) of TLR4 in alveolar macrophages
5) Confidence 0.06 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0 Pain Relevance 0.14
LPS upregulated TLR4 mRNA in both monocytes and alveolar macrophages after 1 h only, and was decreased below basal levels in both cells types after 24 h (Figure 5B).
LPS Positive_regulation (upregulated) of TLR4 in monocytes
6) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.38 Pain Relevance 0.03
TLR4, in contrast was shown to be upregulated in response to LPS on monocytes and alveolar macrophages in a kinetic similar to that of TLR2 using both flow cytometry and qRT-PCR.
LPS Positive_regulation (upregulated) of TLR4 in monocytes
7) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0 Pain Relevance 0.14

General Comments

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