INT294776

Context Info Confidence 0.00 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.17 Pain Relevance 0.10

signal transduction (TLR4) protein modification process (PAM) lyase activity (PAM) extracellular region (PAM) plasma membrane (TLR4) intracellular (TLR4)

Anatomy Link Frequency monocytes 1 PAM (Homo sapiens) TLR4 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 24 71.36 Inflammation 6 5.00 lidocaine 2 5.00 chemokine 2 5.00 anesthesia 1 5.00 adenocard 1 5.00 Inflammatory response 1 5.00 alcohol 1 5.00

Disease Link Frequency Relevance Heat Mycobacterial Infection 27 100.00 INFLAMMATION 7 5.00 Respiratory Disease 3 5.00 Hypersensitivity 2 5.00 Infection 2 5.00 Granuloma 1 5.00 Lung Cancer 1 5.00 Cancer 1 5.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Pam3Cys, LPS, and M.tb DNA upregulated TLR2, TLR4 and TLR9 mRNA in both, bronchoalveolar cells and monocytes.

Pam3Cys Positive_regulation (upregulated) of TLR4 in monocytes associated with mycobacterial infection

1) Confidence 0.00 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2817655 Disease Relevance 0.17 Pain Relevance 0.10

General Comments

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