INT294778

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.41
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR2) protein modification process (PAM) lyase activity (PAM)
extracellular region (PAM) plasma membrane (TLR2) intracellular (TLR2)
Anatomy Link Frequency
alveolar macrophages 2
PAM (Homo sapiens)
TLR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 48 89.60 High High
Inflammation 12 52.88 Quite High
lidocaine 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mycobacterial Infection 54 95.92 Very High Very High Very High
Infection 4 53.92 Quite High
INFLAMMATION 14 52.88 Quite High
Respiratory Disease 6 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low
Granuloma 2 5.00 Very Low Very Low Very Low
Lung Cancer 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pam3Cys induced TLR2 mRNA expression was increased as early as after 1 h in both cells types, but was maintained for a longer time in bronchoalveolar cells.
Pam3Cys Positive_regulation (induced) of Gene_expression (expression) of TLR2 mRNA
1) Confidence 0.01 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0 Pain Relevance 0.09
Pam3Cys upregulated the expression of TLR2 mRNA in monocytes within a 1-hour incubation period only, whereas in alveolar macrophages TLR2 mRNA upregulation was detected after 1 h and then maintained until 24 h (Figure 5A).
Pam3Cys Positive_regulation (upregulated) of Gene_expression (expression) of TLR2 mRNA in alveolar macrophages
2) Confidence 0.01 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.41 Pain Relevance 0.03

General Comments

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