INT294787

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Context Info
Confidence 0.67
First Reported 2010
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.35
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TLR9) signal transduction (TLR9) extracellular region (TLR9)
endoplasmic reticulum (TLR9) plasma membrane (TLR9) intracellular (TLR9)
Anatomy Link Frequency
immune cells 1
TLR9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 38 95.44 Very High Very High Very High
cytokine 34 81.28 Quite High
Central nervous system 16 77.00 Quite High
Inflammatory response 2 76.44 Quite High
Inflammation 29 71.60 Quite High
Bile 6 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 40 95.44 Very High Very High Very High
Infection 50 94.96 High High
Recurrence 16 94.48 High High
INFLAMMATION 26 76.08 Quite High
Disease 34 74.32 Quite High
Neurological Disease 6 56.56 Quite High
Hypersensitivity 2 48.88 Quite Low
Neonatal Necrotizing Enterocolitis 1 16.80 Low Low
Injury 5 13.44 Low Low
Lumbar Puncture Related Headaches 2 10.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantitative real-time PCR (qRT-PCR, TaqMan) was performed to determine the relative TLR2, TLR4 and TLR9 mRNA expression levels using the comparative threshold cycle (??
Spec (determine) Localization (relative) of TLR9 mRNA
1) Confidence 0.67 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0 Pain Relevance 0
Activated via TLR-9, pDCs secrete large amounts of type I interferon [4].
Localization (secrete) of TLR-9
2) Confidence 0.23 Published 2011 Journal J Neuroinflammation Section Body Doc Link PMC3022734 Disease Relevance 1.05 Pain Relevance 0.43
Activated via TLR-9, pDCs also secrete large amounts of type I interferon which are involved either in stimulation or down regulation of immune response in multiple sclerosis (MS).
Localization (secrete) of TLR-9 associated with multiple sclerosis
3) Confidence 0.21 Published 2011 Journal J Neuroinflammation Section Abstract Doc Link PMC3022734 Disease Relevance 0.91 Pain Relevance 0.24
In immune cells, TLR9 is exclusively localized in the endosomes.
Localization (localized) of TLR9 in immune cells
4) Confidence 0.12 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3003996 Disease Relevance 0.39 Pain Relevance 0.07

General Comments

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