INT294895

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.13
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP3A4, CYP2C9) oxidoreductase activity (CYP3A4, CYP2C9) endoplasmic reticulum (CYP3A4, CYP2C9)
enzyme binding (CYP3A4) lipid metabolic process (CYP3A4) cytoplasm (CYP3A4)
CYP3A4 (Homo sapiens)
CYP2C9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 4 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
methadone 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 34 73.56 Quite High
Hypersensitivity 5 31.60 Quite Low
Liver Failure 1 25.52 Quite Low
Exanthema 11 22.12 Low Low
Bullous Skin Disease 2 19.60 Low Low
Staphylococcus Infection 2 18.64 Low Low
Syndrome 2 17.52 Low Low
Sprains And Strains 9 5.00 Very Low Very Low Very Low
Hepatotoxicity 4 5.00 Very Low Very Low Very Low
Infection 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Etravirine is an inducer of CYP3A4, a weak inhibitor of CYP2C9 and a moderate inhibitor of CYP2C19.
CYP3A4 Negative_regulation (inhibitor) of CYP2C9
1) Confidence 0.09 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2817788 Disease Relevance 0.13 Pain Relevance 0

General Comments

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