INT294909

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 5.43
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Pax3) extracellular space (Il6) extracellular region (Il6)
nucleus (Pax3) DNA binding (Pax3)
Anatomy Link Frequency
astrocytes 7
blood 1
Pax3 (Mus musculus)
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 285 100.00 Very High Very High Very High
cytokine 100 95.48 Very High Very High Very High
Neuropeptide 10 88.88 High High
Inflammation 55 82.92 Quite High
chemokine 5 80.80 Quite High
Inflammatory response 5 56.24 Quite High
Central nervous system 5 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Granuloma 460 99.08 Very High Very High Very High
Targeted Disruption 210 97.96 Very High Very High Very High
INFLAMMATION 40 82.92 Quite High
Infection 60 78.72 Quite High
Cyst 60 77.68 Quite High
Anaplastic Astrocytoma 5 69.40 Quite High
Schistosomiasis 10 58.60 Quite High
Mycobacterial Infection 5 51.76 Quite High
Cestode Infection 50 5.00 Very Low Very Low Very Low
Neurocysticercosis 40 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also IL-6 production in human peripheral blood mononuclear cells, bronchial cells, and astrocytes is increased directly by SP through the action of nuclear factor IL-6 (NF-IL-6) and p38 MAPK [26, 27, 34, 35].
SP Positive_regulation (increased) of in astrocytes Gene_expression (production) of IL-6 in blood associated with substance p
1) Confidence 0.09 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817809 Disease Relevance 0.50 Pain Relevance 0.85
IL-6 production in human peripheral blood mononuclear cells, bronchial cells, and astrocytes is increased directly by SP through the action of nuclear factor IL-6 (NF-IL-6) and p38 MAPK, as well as indirectly in response to IL-1?
SP Positive_regulation (increased) of Gene_expression (production) of IL-6 in astrocytes associated with substance p
2) Confidence 0.09 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817809 Disease Relevance 1.52 Pain Relevance 0.29
IL-6 production in human peripheral blood mononuclear cells, bronchial cells, and astrocytes is increased directly by SP through the action of nuclear factor IL-6 (NF-IL-6) and p38 MAPK, as well as indirectly in response to IL-1?
SP Positive_regulation (increased) of Gene_expression (action) of IL-6 in astrocytes associated with substance p
3) Confidence 0.07 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817809 Disease Relevance 1.37 Pain Relevance 0.29
IL-6 production in human peripheral blood mononuclear cells, bronchial cells, and astrocytes is increased directly by SP through the action of nuclear factor IL-6 (NF-IL-6) and p38 MAPK, as well as indirectly in response to IL-1?
SP Positive_regulation (increased) of Gene_expression (action) of IL-6 in astrocytes associated with substance p
4) Confidence 0.07 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817809 Disease Relevance 1.38 Pain Relevance 0.29
Although there are various studies on the molecular mechanisms by which SP stimulates the production of IL-6 and TNF-?
SP Positive_regulation (stimulates) of Gene_expression (production) of IL-6 associated with substance p
5) Confidence 0.06 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817809 Disease Relevance 0.67 Pain Relevance 0.80

General Comments

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