INT294924

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.07
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1) extracellular space (IGF1) extracellular region (IGF1)
Anatomy Link Frequency
pituitary 3
thyroid 2
hypothalamus 1
IGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 2 7.12 Low Low
Bioavailability 5 5.00 Very Low Very Low Very Low
iatrogenic 4 5.00 Very Low Very Low Very Low
Somatostatin 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Clonidine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroid Disease 28 98.72 Very High Very High Very High
Adrenal Cancer 182 88.72 High High
Cretinism 1 86.44 High High
Congenital Anomalies 3 80.60 Quite High
Hypothyroidism 2 78.12 Quite High
Thyroiditis 1 60.84 Quite High
Osteoporosis 2 46.80 Quite Low
Apoptosis 2 39.28 Quite Low
Hypertension 54 25.64 Quite Low
Weight Gain 14 25.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a matter of fact, a direct effect of thyroid function on IGF-I secretion was not fully confirmed in our study, as there were no significant differences in an increase of IGF-I secretion between the euthyroid children and those, who presented with hypothyroidism during rhGH administration.
Regulation (effect) of Localization (secretion) of IGF-I in thyroid associated with thyroid disease
1) Confidence 0.39 Published 2010 Journal Thyroid Res Section Body Doc Link PMC2858102 Disease Relevance 0.79 Pain Relevance 0
Glucocorticoids interfere with the normal interactions in the growth hormone (GH)/IGF-1 signaling cascade at the level of the hypothalamus, pituitary, and target organ as well as adversely affect hormone release, signal and gene transduction, and mRNA processing [36].
Regulation (affect) of Localization (cascade) of IGF-1 in pituitary
2) Confidence 0.09 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2817857 Disease Relevance 0.14 Pain Relevance 0
Glucocorticoids interfere with the normal interactions in the growth hormone (GH)/IGF-1 signaling cascade at the level of the hypothalamus, pituitary, and target organ as well as adversely affect hormone release, signal and gene transduction, and mRNA processing [36].
Regulation (affect) of in hypothalamus Localization (cascade) of IGF-1 in pituitary
3) Confidence 0.03 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2817857 Disease Relevance 0.14 Pain Relevance 0

General Comments

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