INT294932

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.38
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gc) transport (Gc) extracellular space (Gc)
extracellular region (Gc)
Anatomy Link Frequency
pigmentation 1
Gc (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 77 99.60 Very High Very High Very High
Multiple sclerosis 124 99.16 Very High Very High Very High
Demyelination 3 37.76 Quite Low
tolerance 4 13.12 Low Low
Inflammation 8 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
intrathecal 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Sicca syndrome 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sunburn 6 99.70 Very High Very High Very High
Cystic Fibrosis 73 99.60 Very High Very High Very High
Demyelinating Disease 127 99.16 Very High Very High Very High
Disease 73 98.42 Very High Very High Very High
Neurological Disease 2 97.88 Very High Very High Very High
Kidney Stones 41 97.60 Very High Very High Very High
Sprains And Strains 3 94.20 High High
Vitamin Deficiency 9 87.36 High High
Nephrocalcinosis 14 82.48 Quite High
Celiac Disease 3 79.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The hypercalciuria observed in patients with Dent's disease and some ClC-5-deficient mice may be secondary to the PT dysfunction (urinary loss of vitamin D binding protein and reduced phosphate absorption, leading to increased 1,25(OH)2-vitamin D3 synthesis) or, at least in part, caused by the functional loss of ClC-5 in the TAL.
Negative_regulation (loss) of vitamin D binding protein associated with disease and kidney stones
1) Confidence 0.17 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2964617 Disease Relevance 0.98 Pain Relevance 0
Recently, a CSF proteomics study showed that serum levels of vitamin D-binding protein were decreased significantly in RR MScl patients compared to other neurological disorders[35].
Negative_regulation (decreased) of vitamin D-binding protein associated with multiple sclerosis and neurological disease
2) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.19 Pain Relevance 0.45
Decreased storage of both produced and consumed vitamin D may also be due to decreased levels of vitamin D binding protein (DBP) in CF patients, a phenomenon known to exist for 3 decades [26].
Negative_regulation (decreased) of vitamin D binding protein associated with fibrosis
3) Confidence 0.06 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817861 Disease Relevance 0.62 Pain Relevance 0.26
In our experience, the vitamin D levels often decline without maintenance therapy, so we recommend vitamin D doses of 400 to 1000 IU/d or to continue the 50,000 IU of vitamin D2 every 2 to 4 weeks.
Negative_regulation (decline) of vitamin D
4) Confidence 0.05 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.43 Pain Relevance 0
0.0094) in musculoskeletal function detected in patients who received vitamin D and calcium.
Negative_regulation (received) of vitamin D
5) Confidence 0.04 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0 Pain Relevance 0
The major source of vitamin D is sun exposure; thus, active vitamin D in the body can be affected by the season and the duration of direct exposure to sunlight and can be inhibited by sunscreen use and increased skin pigmentation.
Negative_regulation (inhibited) of vitamin D in pigmentation associated with sunburn
6) Confidence 0.04 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.16 Pain Relevance 0

General Comments

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