INT294953

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.63
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PPYR1) signal transducer activity (PPYR1)
PPYR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 2 80.80 Quite High
excitatory amino acid 2 80.40 Quite High
Glutamate receptor 2 79.36 Quite High
agonist 2 78.36 Quite High
sodium channel 16 68.64 Quite High
tetrodotoxin 34 60.48 Quite High
Action potential 2 40.56 Quite Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shellfish Poisoning 8 95.52 Very High Very High Very High
Death 18 85.44 High High
Liver Failure 2 85.04 High High
Paralysis 20 62.00 Quite High
Poisoning 8 53.80 Quite High
Food Poisoning 2 22.72 Low Low
Sprains And Strains 36 5.00 Very Low Very Low Very Low
Toxicity 16 5.00 Very Low Very Low Very Low
Congenital Anomalies 10 5.00 Very Low Very Low Very Low
Spinal Curvatures 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Okadaic acid (OA) (Figure 1) is a polyether produced by Dynophysis species, has a neurotoxic effect and inhibits PP1 and PP2A [12].
Negative_regulation (inhibits) of PP1
1) Confidence 0.03 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2817923 Disease Relevance 0.41 Pain Relevance 0.19
Both PP2A and PP1 were potently inhibited (IC50 = 0.026 and 1.8 nM, respectively) by nodularin, whereas PP2B was inhibited to a lesser extent (IC50 = 8.7 ?
Negative_regulation (inhibited) of PP1
2) Confidence 0.03 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2817923 Disease Relevance 0.22 Pain Relevance 0.29

General Comments

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