INT29496

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Context Info
Confidence 0.75
First Reported 1984
Last Reported 2011
Negated 2
Speculated 6
Reported most in Body
Documents 136
Total Number 143
Disease Relevance 49.49
Pain Relevance 41.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP3) extracellular space (MMP3) extracellular region (MMP3)
proteinaceous extracellular matrix (MMP3) nucleus (MMP3) protein complex (MMP3)
Anatomy Link Frequency
cartilage 7
chondrocytes 5
fibroblasts 5
synovial cells 3
synovial fluids 2
MMP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 2145 100.00 Very High Very High Very High
Osteoarthritis 808 99.92 Very High Very High Very High
cytokine 595 99.82 Very High Very High Very High
Inflammation 870 99.80 Very High Very High Very High
rheumatoid arthritis 482 99.74 Very High Very High Very High
Arthritis 284 99.64 Very High Very High Very High
Infliximab 409 99.36 Very High Very High Very High
Adalimumab 335 99.36 Very High Very High Very High
spinal inflammation 1065 99.12 Very High Very High Very High
endometriosis 92 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 774 100.00 Very High Very High Very High
Osteoarthritis 761 99.92 Very High Very High Very High
Adhesions 85 99.92 Very High Very High Very High
INFLAMMATION 975 99.80 Very High Very High Very High
Rheumatoid Arthritis 497 99.74 Very High Very High Very High
Juvenile Chronic Polyarthritis 94 99.64 Very High Very High Very High
Aggression 12 99.60 Very High Very High Very High
Pancreatic Cancer 112 99.52 Very High Very High Very High
Carcinoma 29 99.48 Very High Very High Very High
Hypercalcemia 22 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HA has been shown to stimulate endogenous HA synthesis by synovial sites through CD 44 receptor binding.12,20 Exogenous HA downregulates matrix metalloproteinase-3 expression and inhibit metalloproteinase synthesis which results in decreased cartilage destruction.
Gene_expression (expression) of matrix metalloproteinase-3 in cartilage associated with metalloproteinase
1) Confidence 0.75 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004653 Disease Relevance 1.09 Pain Relevance 0.91
Hyaluronate inhibits the interleukin-1beta-induced expression of matrix metalloproteinase (MMP)-1 and MMP-3 in human synovial cells.
Gene_expression (expression) of MMP-3 in synovial cells associated with metalloproteinase
2) Confidence 0.68 Published 2004 Journal Tohoku J. Exp. Med. Section Title Doc Link 15383690 Disease Relevance 0.27 Pain Relevance 0.70
We therefore prepose that intra-articular HA may rescue inflamed joints from bone and cartilage destruction by reducing the production of MMP-1 and MMP-3.
Gene_expression (production) of MMP-3 in cartilage associated with metalloproteinase
3) Confidence 0.68 Published 2004 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 15383690 Disease Relevance 0.06 Pain Relevance 0.75
These data suggest that HA inhibits the expression and production of MMP-1 and MMP-3 in IL-1beta-stimulated human synovial cells.
Gene_expression (expression) of MMP-3 in synovial cells associated with metalloproteinase
4) Confidence 0.68 Published 2004 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 15383690 Disease Relevance 0.18 Pain Relevance 0.88
IL-8, MMP-1 and MMP-3 were detected in all culture medium samples of cervical fibroblasts.
Gene_expression (detected) of MMP-3 in fibroblasts associated with metalloproteinase
5) Confidence 0.67 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639405 Disease Relevance 0.05 Pain Relevance 0.78
The levels of MMP-1 and MMP-3 were not significantly changed by CRH (Fig. 4B and C).
Gene_expression (levels) of MMP-3 associated with metalloproteinase
6) Confidence 0.67 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639405 Disease Relevance 0 Pain Relevance 0.76
Assessment of matrix metalloproteinase-3 in synovial fluids
Gene_expression (Assessment) of matrix metalloproteinase-3 in synovial fluids associated with metalloproteinase
7) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575633 Disease Relevance 0.17 Pain Relevance 0.22
Preincubation with ciprofloxacin potentiated IL-1beta-stimulated MMP-3 output, reflecting a similar effect on MMP-3 mRNA expression.
Gene_expression (expression) of MMP-3 mRNA
8) Confidence 0.67 Published 2002 Journal Arthritis Rheum. Section Body Doc Link 12428247 Disease Relevance 0.10 Pain Relevance 0
RESULTS: Unstimulated tendon cells expressed low or undetectable levels of MMP-1 and MMP-3, and substantial levels of MMP-2.
Gene_expression (levels) of MMP-3 in tendon cells
9) Confidence 0.67 Published 2002 Journal Arthritis Rheum. Section Body Doc Link 12428247 Disease Relevance 0.14 Pain Relevance 0
Ciprofloxacin enhances the stimulation of matrix metalloproteinase 3 expression by interleukin-1beta in human tendon-derived cells.
Gene_expression (expression) of matrix metalloproteinase 3 in tendon associated with metalloproteinase
10) Confidence 0.67 Published 2002 Journal Arthritis Rheum. Section Title Doc Link 12428247 Disease Relevance 0.10 Pain Relevance 0.19
RESULTS: Unstimulated tendon cells expressed low or undetectable levels of MMP-1 and MMP-3, and substantial levels of MMP-2.
Gene_expression (expressed) of MMP-3 in tendon cells
11) Confidence 0.67 Published 2002 Journal Arthritis Rheum. Section Body Doc Link 12428247 Disease Relevance 0.14 Pain Relevance 0
They showed a correlation for MMP1 expression and tumour aggressiveness, but no detectable expression for MMP3.
Neg (no) Gene_expression (expression) of MMP3 associated with cancer and aggression
12) Confidence 0.66 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 1.11 Pain Relevance 0.17
One group investigated MMP1 and MMP3 protein expression by immunohistochemistry [15].
Spec (investigated) Gene_expression (expression) of MMP3
13) Confidence 0.66 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 1.10 Pain Relevance 0.20
However, changes in both MMP3 and MMP13 gene expression are rapid, dramatic, sustained, and changing during at least the first 48 h of unloaded culture.
Gene_expression (expression) of MMP3
14) Confidence 0.65 Published 2008 Journal J. Orthop. Res. Section Abstract Doc Link 18404723 Disease Relevance 0.36 Pain Relevance 0.10
In vitro studies to identify mechanisms of actions of Aflapin: Effect on expression of ICAM-1 and MMP3
Gene_expression (expression) of MMP3
15) Confidence 0.63 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2974165 Disease Relevance 0.26 Pain Relevance 0.16
Interleukin 6 (IL-6) and IL-8, stromelysin [matrix metalloproteinase-3 (MMP-3)], and aggrecan (AGG) production were assayed by specific enzyme amplified sensitivity immunoassays, and prostaglandin E2 (PGE2) production by specific radioimmunoassay.
Gene_expression (production) of matrix metalloproteinase-3 in PGE2
16) Confidence 0.60 Published 2002 Journal J. Rheumatol. Section Body Doc Link 11950021 Disease Relevance 0 Pain Relevance 0
Interleukin 6 (IL-6) and IL-8, stromelysin [matrix metalloproteinase-3 (MMP-3)], and aggrecan (AGG) production were assayed by specific enzyme amplified sensitivity immunoassays, and prostaglandin E2 (PGE2) production by specific radioimmunoassay.
Gene_expression (production) of MMP-3 in PGE2
17) Confidence 0.60 Published 2002 Journal J. Rheumatol. Section Body Doc Link 11950021 Disease Relevance 0 Pain Relevance 0
The expression of MMP-1 and MMP-3 mRNAs was analyzed by quantitative real-time polymerase chain reaction.
Spec (analyzed) Gene_expression (expression) of MMP-3 associated with metalloproteinase
18) Confidence 0.59 Published 2004 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 15383690 Disease Relevance 0.25 Pain Relevance 0.79
Expression of MMP-1 and MMP-3 mRNAs was induced by IL-1beta.
Gene_expression (Expression) of MMP-3 associated with metalloproteinase
19) Confidence 0.59 Published 2004 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 15383690 Disease Relevance 0.23 Pain Relevance 0.88
Assessment of MMP-3 concentration
Gene_expression (concentration) of MMP-3
20) Confidence 0.58 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575633 Disease Relevance 0.51 Pain Relevance 0.36

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