INT294979

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Context Info
Confidence 0.58
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.22
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (BDP1) nucleus (BDP1) DNA binding (BDP1)
BDP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 4 65.68 Quite High
Ziconotide 4 62.72 Quite High
alcohol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 40 99.84 Very High Very High Very High
Stress 40 96.92 Very High Very High Very High
Apoptosis 88 96.48 Very High Very High Very High
Malignant Neoplastic Disease 4 95.32 Very High Very High Very High
Death 12 76.16 Quite High
Ovarian Cancer 4 73.80 Quite High
Colon Cancer 24 72.96 Quite High
Pain 4 65.68 Quite High
Recurrence 4 33.08 Quite Low
Lung Cancer 4 25.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TfnR is constitutively expressed in cancer cells, up to 4- to 5-fold higher than nonneoplastic cells because of the need for iron as a cofactor of DNA synthesis of rapidly dividing cells.
Gene_expression (expressed) of TfnR associated with cancer
1) Confidence 0.58 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2817924 Disease Relevance 0.51 Pain Relevance 0.13
Abnormal expression of Tfn/TfnR results in an unbalanced iron homeostasis that is associated with oxidative stress and programmed cell death [10] which has been well documented in HT29 cells treated with flavone [11], or tangutorine [12].
Gene_expression (expression) of TfnR associated with stress and apoptosis
2) Confidence 0.58 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2817924 Disease Relevance 0.88 Pain Relevance 0.05
TfnR is up-regulated in cancer cells for enhancing iron uptake, and iron depletion by iron chelators or decreased expression of Tfn and TfnR have been proven to be effective in the treatment of cancer [10,21].
Gene_expression (expression) of TfnR associated with cancer
3) Confidence 0.45 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2817924 Disease Relevance 0.38 Pain Relevance 0
The increase of cellular iron uptake is associated with an increased expression of iron import proteins, such as Tfn and TfnR [21].
Gene_expression (expression) of TfnR
4) Confidence 0.45 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2817924 Disease Relevance 0.44 Pain Relevance 0

General Comments

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