INT294991

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.08
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (ABCC8) ATPase activity (ABCC8) plasma membrane (ABCC8)
carbohydrate metabolic process (ABCC8) transmembrane transport (ABCC8)
ABCC8 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 20 93.28 High High
aspirin 12 57.28 Quite High
cINOD 28 36.96 Quite Low
corticosteroid 8 28.76 Quite Low
Inflammation 12 24.64 Low Low
Arthritis 20 5.00 Very Low Very Low Very Low
withdrawal 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Rheumatism 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Crystal Associated Disease 388 99.32 Very High Very High Very High
Recurrence 12 98.96 Very High Very High Very High
Diuresis 8 95.92 Very High Very High Very High
Obesity 12 92.92 High High
Hypertension 20 83.36 Quite High
Myocardial Infarction 8 73.60 Quite High
Disorders Of Creatine Metabolism 20 55.24 Quite High
Hyperuricemia 56 53.44 Quite High
Adverse Drug Reaction 12 41.32 Quite Low
Syndrome 8 40.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Febuxostat 10 to 120 mg/day dose-dependently reduced mean sUr levels from baseline by 25% to 70% in healthy volunteers; 24-hour urinary uric acid excretion at day 8 was decreased by 46% to 66% relative to placebo.58 Both effects seemed to plateau at dosages >120 mg/day.58 Age (18 to 40 years versus ?
Negative_regulation (reduced) of sUr
1) Confidence 0.17 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2817937 Disease Relevance 0.11 Pain Relevance 0
Sustained reduction of sUr was associated with nearly complete elimination of gout flares.
Negative_regulation (reduction) of sUr associated with crystal associated disease
2) Confidence 0.17 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2817937 Disease Relevance 0.46 Pain Relevance 0
Dietary measures are very important.32 However, a strict low-purine diet can achieve only a limited reduction in sUr levels (?
Negative_regulation (reduction) of sUr
3) Confidence 0.12 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2817937 Disease Relevance 1.28 Pain Relevance 0.07
When gout has subsided, it is important to reduce the sUr concentration to prevent recurrence of gouty attacks.
Negative_regulation (reduce) of sUr associated with crystal associated disease and recurrence
4) Confidence 0.12 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2817937 Disease Relevance 1.23 Pain Relevance 0.11

General Comments

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