INT29500

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Context Info
Confidence 0.53
First Reported 1987
Last Reported 2009
Negated 1
Speculated 1
Reported most in Title
Documents 3
Total Number 4
Disease Relevance 0.47
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Mmp2) cytoplasm (Mmp2) extracellular space (Mmp2)
peptidase activity (Mmp2) extracellular region (Mmp2) proteinaceous extracellular matrix (Mmp2)
Anatomy Link Frequency
neutrophils 4
stromal cells 2
Mmp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 10 100.00 Very High Very High Very High
cINOD 6 100.00 Very High Very High Very High
Dismenorea 4 98.16 Very High Very High Very High
aspirin 2 60.84 Quite High
cytokine 7 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 3 100.00 Very High Very High Very High
Dysmenorrhea 4 98.16 Very High Very High Very High
Pleurisy 2 87.44 High High
Death 2 5.00 Very Low Very Low Very Low
Infection 2 5.00 Very Low Very Low Very Low
Reprotox - General 1 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Pre-term Labor 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have examined the effects of auranofin and some nonsteroidal anti-inflammatory drugs (NSAID) on the release of gelatinase from rat neutrophils.
Spec (examined) Regulation (effects) of Localization (release) of gelatinase in neutrophils associated with inflammation and cinod
1) Confidence 0.53 Published 1987 Journal Int J Tissue React Section Abstract Doc Link 2834302 Disease Relevance 0.19 Pain Relevance 0.20
Genes such as gelatinase A (MMP2), cathepsin L, tissue inhibitor metalloproteinases 2 (TIMP2) and 3 (TIMP3), plasminogen activator inhibitor1 (PAI1), tissue type plasminogen activator (tPA), urokinase plasminogen activator (uPA), endothelin 1, calponin, carboxypeptidase D and calponin acidic were down regulated.
Regulation (regulated) of Localization (tissue) of MMP2 associated with metalloproteinase
2) Confidence 0.32 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0.05
Auranofin modulates gelatinase release from rat neutrophils.
Regulation (modulates) of Localization (release) of gelatinase in neutrophils
3) Confidence 0.23 Published 1987 Journal Int J Tissue React Section Title Doc Link 2834302 Disease Relevance 0.18 Pain Relevance 0.28
Increased matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 secretion but unaffected invasiveness of endometrial stromal cells in adenomyosis.
Neg (unaffected) Regulation (unaffected) of Localization (secretion) of matrix metalloproteinase-2 in stromal cells associated with dismenorea and metalloproteinase
4) Confidence 0.04 Published 2009 Journal Fertil. Steril. Section Title Doc Link 18692810 Disease Relevance 0.10 Pain Relevance 0.38

General Comments

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