INT295000

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Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.27
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Tnfsf11) extracellular space (Tnfsf11) extracellular region (Tnfsf11)
plasma membrane (Tnfsf11) intracellular (Tnfsf11) response to stress (Tnfsf11)
Anatomy Link Frequency
joint 1
osteoblasts 1
bone marrow 1
Tnfsf11 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 154 96.00 Very High Very High Very High
antagonist 5 53.52 Quite High
agonist 4 51.04 Quite High
Inflammation 20 40.16 Quite Low
imagery 2 30.16 Quite Low
psoriasis 38 16.72 Low Low
rheumatoid arthritis 10 5.00 Very Low Very Low Very Low
Bioavailability 5 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Potency 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Seronegative Spondarthritis 134 96.00 Very High Very High Very High
Breast Cancer 2 94.84 High High
Osteoporosis 17 91.12 High High
Respiratory Syncytial Virus 116 89.08 High High
Osteolysis 18 83.92 Quite High
Hypercalcemia 28 82.44 Quite High
Disease 30 82.08 Quite High
Rickets 4 77.24 Quite High
Hypocalcemia 2 76.12 Quite High
Stress 1 73.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the osteoblasts and the bone marrow stromal cells produce RANKL which activates the osteoclasts by binding to its RANK receptor.
RANKL Binding (binding) of in bone marrow
1) Confidence 0.32 Published 2010 Journal Nutr J Section Body Doc Link PMC2818614 Disease Relevance 0.47 Pain Relevance 0
The osteoblasts also produce OPG which functions as a decoy receptor and binds RANKL and thereby prevents it from binding to RANK [2,7].
RANKL Binding (binds) of in osteoblasts
2) Confidence 0.29 Published 2010 Journal Nutr J Section Body Doc Link PMC2818614 Disease Relevance 0.50 Pain Relevance 0
B acts as a common transcriptional factor for both RANKL and AhR-mediated signaling.
RANKL Binding (factor) of
3) Confidence 0.16 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.53 Pain Relevance 0.05
Our data indicate that the extent of bone loss at the peripheral joint is associated with elevated circulating M-CSF and RANKL concentrations, but that these factors are not associated with the extent of systemic bone loss in PsA.
RANKL Binding (associated) of in joint associated with arthritis
4) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945067 Disease Relevance 0.77 Pain Relevance 0.27
MEM with RANKL and M-CSF for 14 days on ivory slices in duplicate (supplied by the Auckland Conservancy Office, Department of Conservation, Auckland, New Zealand).
RANKL Binding (MEM) of
5) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945067 Disease Relevance 0 Pain Relevance 0

General Comments

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