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Context Info
Confidence 0.20
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.02
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Tnfsf11) extracellular space (Tnfsf11) signal transduction (TNFRSF11A)
extracellular region (Tnfsf11) plasma membrane (Tnfsf11) intracellular (Tnfsf11)
Anatomy Link Frequency
stromal cells 1
bone marrow 1
TNFRSF11A (Homo sapiens)
Tnfsf11 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 3 74.56 Quite High
Arthritis 77 60.08 Quite High
psoriasis 19 51.32 Quite High
Inflammation 12 47.00 Quite Low
corticosteroid 2 16.92 Low Low
cva 10 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
rheumatoid arthritis 5 5.00 Very Low Very Low Very Low
peripheral neuropathy 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 10 99.32 Very High Very High Very High
Bone Cancer 10 95.88 Very High Very High Very High
Hypercalcemia 9 88.00 High High
Multiple Myeloma 29 82.52 Quite High
Rickets 2 77.24 Quite High
Hypocalcemia 1 76.12 Quite High
Herpes Zoster 2 75.20 Quite High
Ankylosis 1 71.80 Quite High
Sunburn 1 70.04 Quite High
Osteolysis 9 63.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the osteoblasts and the bone marrow stromal cells produce RANKL which activates the osteoclasts by binding to its RANK receptor.
RANK Binding (binding) of RANKL in bone marrow
1) Confidence 0.20 Published 2010 Journal Nutr J Section Body Doc Link PMC2818614 Disease Relevance 0.47 Pain Relevance 0
The RANK ligand (RANKL) and a regulatory protein, osteoprotegerin, produced by stromal cells both bind RANK.
RANK Binding (ligand) of RANKL in stromal cells
2) Confidence 0.03 Published 2010 Journal Advances in Hematology Section Body Doc Link PMC2905716 Disease Relevance 1.08 Pain Relevance 0.04
Osteoprotegerin (OPG) is a further mediator of bone remodeling, acting as a decoy receptor that prevents RANKL binding to its receptor RANK, thus inhibiting osteoclastogenesis [7].
RANK Binding (binding) of RANKL
3) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945067 Disease Relevance 0.47 Pain Relevance 0.06

General Comments

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