INT295006

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.60
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFRSF11A, Tnfrsf11b) extracellular space (Tnfrsf11b) extracellular region (Tnfrsf11b)
proteinaceous extracellular matrix (Tnfrsf11b) extracellular matrix organization (Tnfrsf11b) cell-cell signaling (TNFRSF11A)
Anatomy Link Frequency
stromal cells 1
osteoblasts 1
TNFRSF11A (Homo sapiens)
Tnfrsf11b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 1 78.00 Quite High
corticosteroid 2 16.92 Low Low
cva 10 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
peripheral neuropathy 4 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
induced neuropathy 2 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 7 99.32 Very High Very High Very High
Bone Cancer 4 95.88 Very High Very High Very High
Hypercalcemia 7 88.00 High High
Multiple Myeloma 29 82.52 Quite High
Herpes Zoster 2 75.20 Quite High
Rickets 2 73.24 Quite High
Hypocalcemia 1 72.12 Quite High
Sunburn 1 66.04 Quite High
Influenza Virus Infection 1 59.44 Quite High
Overweight 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The osteoblasts also produce OPG which functions as a decoy receptor and binds RANKL and thereby prevents it from binding to RANK [2,7].
RANK Binding (binding) of OPG in osteoblasts
1) Confidence 0.10 Published 2010 Journal Nutr J Section Body Doc Link PMC2818614 Disease Relevance 0.51 Pain Relevance 0
The RANK ligand (RANKL) and a regulatory protein, osteoprotegerin, produced by stromal cells both bind RANK.
RANK Binding (ligand) of osteoprotegerin in stromal cells
2) Confidence 0.02 Published 2010 Journal Advances in Hematology Section Body Doc Link PMC2905716 Disease Relevance 1.09 Pain Relevance 0.04

General Comments

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