INT29501

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Context Info
Confidence 0.60
First Reported 1987
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.42
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Mmp2) cytoplasm (Mmp2) extracellular space (Mmp2)
peptidase activity (Mmp2) extracellular region (Mmp2) proteinaceous extracellular matrix (Mmp2)
Anatomy Link Frequency
neutrophils 4
stromal cells 2
Mmp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 4 100.00 Very High Very High Very High
Dismenorea 2 97.56 Very High Very High Very High
cINOD 6 96.72 Very High Very High Very High
aspirin 2 96.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Dysmenorrhea 2 97.56 Very High Very High Very High
Pleurisy 2 91.32 High High
INFLAMMATION 2 82.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Control, blood-derived neutrophils exposed to STZ produced more than a four-fold increase in the release of gelatinase, a response significantly inhibited by the presence of auranofin at 10(-5) and 10(-4) M.
Positive_regulation (increase) of Localization (release) of gelatinase in neutrophils
1) Confidence 0.60 Published 1987 Journal Int J Tissue React Section Abstract Doc Link 2834302 Disease Relevance 0.17 Pain Relevance 0.27
The release of gelatinase by control neutrophils (no stimulation) or by neutrophils exposed to Con A was enhanced by 10(-6) M auranofin.
Positive_regulation (enhanced) of Localization (release) of gelatinase in neutrophils
2) Confidence 0.40 Published 1987 Journal Int J Tissue React Section Abstract Doc Link 2834302 Disease Relevance 0.15 Pain Relevance 0.29
Increased matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 secretion but unaffected invasiveness of endometrial stromal cells in adenomyosis.
Positive_regulation (Increased) of Localization (secretion) of matrix metalloproteinase-2 in stromal cells associated with dismenorea and metalloproteinase
3) Confidence 0.04 Published 2009 Journal Fertil. Steril. Section Title Doc Link 18692810 Disease Relevance 0.10 Pain Relevance 0.38

General Comments

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