INT29502

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Context Info
Confidence 0.79
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 3.49
Pain Relevance 4.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Mmp2) cytoplasm (Mmp2) extracellular space (Mmp2)
peptidase activity (Mmp2) extracellular region (Mmp2) proteinaceous extracellular matrix (Mmp2)
Anatomy Link Frequency
neutrophils 8
lung 2
neuronal 1
stromal cells 1
interstitial cells 1
Mmp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 213 100.00 Very High Very High Very High
cINOD 24 99.82 Very High Very High Very High
aspirin 8 98.24 Very High Very High Very High
Dismenorea 4 97.56 Very High Very High Very High
Inflammation 25 95.20 Very High Very High Very High
ischemia 13 93.40 High High
dexamethasone 27 91.64 High High
anesthesia 11 84.20 Quite High
fibrosis 43 38.56 Quite Low
imagery 3 21.36 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 33 99.56 Very High Very High Very High
Pleurisy 8 98.76 Very High Very High Very High
Dysmenorrhea 4 97.56 Very High Very High Very High
Injury 32 97.36 Very High Very High Very High
Convulsion 1 94.56 High High
Cv General 4 Under Development 4 93.76 High High
Bronchopulmonary Dysplasia 183 81.20 Quite High
Muscle Hypotonia 1 76.20 Quite High
Genetic Predisposition To Disease 9 74.64 Quite High
Hypoxia 40 74.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that auranofin is an effective inhibitor of gelatinase release from neutrophils and this property may represent a contributory factor assigned to the beneficial therapeutic action of gold salts.
Localization (release) of gelatinase in neutrophils
1) Confidence 0.79 Published 1987 Journal Int J Tissue React Section Abstract Doc Link 2834302 Disease Relevance 0.13 Pain Relevance 0.26
Furthermore, an immunoblot study demonstrated that relaxin stimulated the secretion of a 72-kDa type IV collagenase-like substance from cultured theca-interstitial cells but not from granulosa cells.
Localization (secretion) of 72-kDa type IV collagenase in interstitial cells
2) Confidence 0.78 Published 1996 Journal Biol. Reprod. Section Abstract Doc Link 8949884 Disease Relevance 0 Pain Relevance 0.05
Inflamed, pleural neutrophils exposed to STZ produced a doubling in gelatinase release and this was also inhibited by auranofin at 10(-5) and 10(-4) M.
Localization (release) of gelatinase in neutrophils
3) Confidence 0.70 Published 1987 Journal Int J Tissue React Section Abstract Doc Link 2834302 Disease Relevance 0.16 Pain Relevance 0.27
Control, blood-derived neutrophils exposed to STZ produced more than a four-fold increase in the release of gelatinase, a response significantly inhibited by the presence of auranofin at 10(-5) and 10(-4) M.
Localization (release) of gelatinase in neutrophils
4) Confidence 0.69 Published 1987 Journal Int J Tissue React Section Abstract Doc Link 2834302 Disease Relevance 0.17 Pain Relevance 0.27
In contrast, the NSAIDs aspirin, piroxicam, sulindac, indomethacin and naproxen had no inhibitory action on neutrophil gelatinase release.
Localization (release) of gelatinase in neutrophil associated with aspirin and cinod
5) Confidence 0.69 Published 1987 Journal Int J Tissue React Section Abstract Doc Link 2834302 Disease Relevance 0.13 Pain Relevance 0.27
We have examined the effects of auranofin and some nonsteroidal anti-inflammatory drugs (NSAID) on the release of gelatinase from rat neutrophils.
Localization (release) of gelatinase in neutrophils associated with inflammation and cinod
6) Confidence 0.69 Published 1987 Journal Int J Tissue React Section Abstract Doc Link 2834302 Disease Relevance 0.19 Pain Relevance 0.20
Auranofin modulates gelatinase release from rat neutrophils.
Localization (release) of gelatinase in neutrophils
7) Confidence 0.69 Published 1987 Journal Int J Tissue React Section Title Doc Link 2834302 Disease Relevance 0.18 Pain Relevance 0.28
Quantitative analysis and localization of mRNA transcripts of type I collagen, osteocalcin, MMP 2, MMP 8, and MMP 13 during bone healing in a rat calvarial experimental defect model.
Localization (localization) of MMP 2
8) Confidence 0.68 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Title Doc Link 18615687 Disease Relevance 0 Pain Relevance 0.31
Both neutrophil preparations released gelatinase in response to stimulation by serum-treated zymosan (STZ) or concanavalin A (Con A).
Localization (released) of gelatinase in neutrophil
9) Confidence 0.61 Published 1987 Journal Int J Tissue React Section Abstract Doc Link 2834302 Disease Relevance 0.19 Pain Relevance 0.26
The release of gelatinase by control neutrophils (no stimulation) or by neutrophils exposed to Con A was enhanced by 10(-6) M auranofin.
Localization (release) of gelatinase in neutrophils
10) Confidence 0.61 Published 1987 Journal Int J Tissue React Section Abstract Doc Link 2834302 Disease Relevance 0.15 Pain Relevance 0.28
Since previous studies showed that these MMPs were co-localized with the type IV collagen in the basement membrane,3 the MMP-2 and MMP-9 in this early phase secreted by macrophages and neutrophils may play an important role in degrading the basement membrane, thereby facilitating the inflammatory cell migration.
Localization (secreted) of MMP-2 in basement membrane associated with inflammation and metalloproteinase
11) Confidence 0.59 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.39 Pain Relevance 0.82
Among secreted MMPs, MMP2 is known to play a key role in lung development and repair after injury.
Localization (secreted) of MMP2 in lung associated with injury and metalloproteinase
12) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.49 Pain Relevance 0.33
Genes such as gelatinase A (MMP2), cathepsin L, tissue inhibitor metalloproteinases 2 (TIMP2) and 3 (TIMP3), plasminogen activator inhibitor1 (PAI1), tissue type plasminogen activator (tPA), urokinase plasminogen activator (uPA), endothelin 1, calponin, carboxypeptidase D and calponin acidic were down regulated.
Localization (tissue) of MMP2 associated with metalloproteinase
13) Confidence 0.53 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0.05
MMP2 measurements in tracheal aspirates
Localization (measurements) of MMP2
14) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.05 Pain Relevance 0.13
Although its role in lung development has not previously been studied, its ability to localize on the cell membrane and to activate pro-MMP2 has been clearly demonstrated.
Localization (localize) of MMP2 in lung
15) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.42 Pain Relevance 0.22
Homogenates were immunoblotted with occludin and claudin-5 (Zymed Laboratories, Carlsbad, CA), collagen IV (Abcam, Cambridge, MA), MMP-2, and MMP-9 (Calbiochem, Gibbstown, NJ) antibodies, respectively.
Localization (immunoblotted) of MMP-2 associated with metalloproteinase
16) Confidence 0.43 Published 2010 Journal Diabetes Section Body Doc Link PMC2797926 Disease Relevance 0.11 Pain Relevance 0.17
The primarily neuronal localization of the net MMP gelatinase activity after global HI and resuscitation is in agreement with previous studies at relatively early time points after kainate-induced seizures and global cerebral ischemia [13], [37].
Localization (localization) of gelatinase in neuronal associated with convulsion, cv general 4 under development and ischemia
17) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000320 Disease Relevance 0.61 Pain Relevance 0.09
Increased matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 secretion but unaffected invasiveness of endometrial stromal cells in adenomyosis.
Localization (secretion) of matrix metalloproteinase-2 in stromal cells associated with dismenorea and metalloproteinase
18) Confidence 0.06 Published 2009 Journal Fertil. Steril. Section Title Doc Link 18692810 Disease Relevance 0.10 Pain Relevance 0.38

General Comments

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