INT29503

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Context Info
Confidence 0.77
First Reported 1987
Last Reported 2010
Negated 2
Speculated 4
Reported most in Body
Documents 95
Total Number 100
Disease Relevance 56.92
Pain Relevance 31.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Mmp2) cytoplasm (Mmp2) extracellular space (Mmp2)
peptidase activity (Mmp2) extracellular region (Mmp2) proteinaceous extracellular matrix (Mmp2)
Anatomy Link Frequency
endometrium 8
epithelial cells 6
ECM 4
corneas 4
plasma 3
Mmp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 2385 100.00 Very High Very High Very High
Angina 8 99.84 Very High Very High Very High
fibrosis 680 99.72 Very High Very High Very High
Desipramine 3 99.72 Very High Very High Very High
antidepressant 27 99.64 Very High Very High Very High
Inflammatory mediators 6 99.36 Very High Very High Very High
Dismenorea 57 99.16 Very High Very High Very High
chemokine 20 99.04 Very High Very High Very High
fluoxetine 3 99.04 Very High Very High Very High
cytokine 253 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bronchopulmonary Dysplasia 488 100.00 Very High Very High Very High
Injury 491 99.96 Very High Very High Very High
Glioma 216 99.84 Very High Very High Very High
Cv General 3 Under Development 15 99.84 Very High Very High Very High
Breast Cancer 9 99.84 Very High Very High Very High
Adult Respiratory Distress Syndrome 73 99.76 Very High Very High Very High
Pituitary Cancer 11 99.60 Very High Very High Very High
Fibrosis 421 99.50 Very High Very High Very High
Myocardial Infarction 25 99.44 Very High Very High Very High
Reperfusion Injury 489 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The influence of distinct classes of antidepressants, namely, electroconvulsive seizure, fluoxetine, tranylcypromine, and desipramine, on the gene expression of MMP-2, MMP-9, and TIMPs 1-4 in the hippocampus was determined using radioactive in situ hybridization.
Gene_expression (expression) of MMP-2 in hippocampus associated with desipramine, antidepressant, convulsion, hippocampus and fluoxetine
1) Confidence 0.77 Published 2008 Journal Synapse Section Abstract Doc Link 18509851 Disease Relevance 0.17 Pain Relevance 0.75
Acute and chronic pharmacological antidepressants on the other hand differentially alter the expression of the TIMPs without any observed effect on hippocampal MMP-2/9 expression or activity.
Gene_expression (expression) of MMP-2 associated with antidepressant
2) Confidence 0.77 Published 2008 Journal Synapse Section Abstract Doc Link 18509851 Disease Relevance 0.07 Pain Relevance 0.73
Collagen, hexosamine and gelatinase expressions were also well correlative with the healing pattern observed.
Gene_expression (expressions) of gelatinase
3) Confidence 0.67 Published 2002 Journal J Ethnopharmacol Section Abstract Doc Link 12426086 Disease Relevance 1.21 Pain Relevance 0.21
Inflamed, pleural neutrophils exposed to STZ produced a doubling in gelatinase release and this was also inhibited by auranofin at 10(-5) and 10(-4) M.
Gene_expression (produced) of gelatinase in neutrophils
4) Confidence 0.66 Published 1987 Journal Int J Tissue React Section Abstract Doc Link 2834302 Disease Relevance 0.16 Pain Relevance 0.27
CONCLUSION: This study provides preliminary evidence that topical application of some NSAIDs can induce the early expression of MMP-1, MMP-2, and MMP-8 in the cornea, suggesting that MMPs play a role in the corneal cytotoxicity of certain NSAIDs.


Gene_expression (expression) of MMP-2 in cornea
5) Confidence 0.64 Published 2003 Journal J Cataract Refract Surg Section Body Doc Link 12781288 Disease Relevance 0 Pain Relevance 0
RESULTS: Matrix metalloproteinase-1, MMP-8, and MMP-2 were detected in rat corneas at 48 hours in the debrided and intact epithelium groups treated with NSAID eyedrops.
Gene_expression (detected) of MMP-2 in corneas
6) Confidence 0.64 Published 2003 Journal J Cataract Refract Surg Section Body Doc Link 12781288 Disease Relevance 0.05 Pain Relevance 0
After the 14th day when fibrosis progressed, the overall expression of the MMP-2 and MMP-9 was very low.
Gene_expression (expression) of MMP-2 associated with fibrosis and metalloproteinase
7) Confidence 0.62 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.93 Pain Relevance 0.86
TGF-beta 1, the most potent fibrogenic cytokine, has been reported to increase in pulmonary fibrosis and to be expressed in alveolar epithelial cells in higher levels even in later phase of pulmonary fibrosis.37,38 It was also reported that TGF-beta 1 induces transition of alveolar epithelial cells to mesenchymal/fibroblasts-like cells and MMP-2 expression in those cells,39 possibly suggesting that MMP-2 production in alveolar epithelial cells by TGF-beta 1 may promote pulmonary fibrosis.
Gene_expression (production) of MMP-2 in epithelial cells associated with fibrosis, metalloproteinase, pulmonary fibrosis and cytokine
8) Confidence 0.62 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.72 Pain Relevance 1.01
Especially, those with the features of cellular injury, such as cellular swelling, vacuolization, and nuclear atypia, expressed MMP-2 and MMP-9 more prominently.
Gene_expression (expressed) of MMP-2 associated with injury, metalloproteinase and edema
9) Confidence 0.62 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.65 Pain Relevance 0.87
MMP-9 was almost exclusively stained in the neutrophils, whereas MMP-2 was expressed more strongly in the macrophages.
Gene_expression (expressed) of MMP-2 in macrophages associated with metalloproteinase
10) Confidence 0.62 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.58 Pain Relevance 0.60
Bronchiolization, frequently observed from 4th to 7th day, is regarded as a reparative reaction to cellular injury to the alveolar epithelial cells.15,26 Also, cells surrounding the fibrotic foci are known to be derived from regenerating pneumocytes.27 The fact that the MMP-2 and MMP-9 were expressed in the cells with features of cellular injury/repair may suggest the roles of MMP-2 and MMP-9 in cellular regeneration.
Gene_expression (expressed) of MMP-2 in epithelial cells associated with fibrosis, injury and metalloproteinase
11) Confidence 0.62 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 1.07 Pain Relevance 0.86
In saline-instilled control groups, MMP-2 and MMP-9 were expressed in moderate degrees in the bronchiolar epithelial cells and smooth muscle cells in the arteriolar wall, and weakly expressed in a few alveolar macrophages and type II pneumocytes as well as in some lymphocytes around the arterioles and bronchioles.
Gene_expression (expressed) of MMP-2 in epithelial cells associated with metalloproteinase
12) Confidence 0.62 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.66 Pain Relevance 0.31
Although there was no statistically significant difference in the expression between the MMP-2 and MMP-9, MMP-2 appeared to be expressed at a higher level on the 4th day, compared to MMP-9 and also showed a tendency to decline less rapidly (Fig. 5).


Gene_expression (expressed) of MMP-2 associated with metalloproteinase
13) Confidence 0.62 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.28 Pain Relevance 0.68
The overall expression of MMP-2 and MMP-9 along the time sequence dynamically changed according to the immunohistochemical score.
Gene_expression (expression) of MMP-2 associated with metalloproteinase
14) Confidence 0.62 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.48 Pain Relevance 0.69
TGF-beta 1, the most potent fibrogenic cytokine, has been reported to increase in pulmonary fibrosis and to be expressed in alveolar epithelial cells in higher levels even in later phase of pulmonary fibrosis.37,38 It was also reported that TGF-beta 1 induces transition of alveolar epithelial cells to mesenchymal/fibroblasts-like cells and MMP-2 expression in those cells,39 possibly suggesting that MMP-2 production in alveolar epithelial cells by TGF-beta 1 may promote pulmonary fibrosis.
Gene_expression (expression) of MMP-2 in epithelial cells associated with fibrosis, metalloproteinase, pulmonary fibrosis and cytokine
15) Confidence 0.62 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.73 Pain Relevance 0.99
Zhou et al found increased MMP2 expression and activity in their ?
Gene_expression (expression) of MMP2
16) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827566 Disease Relevance 0.49 Pain Relevance 0.18
Given the hippocampal structural remodeling associated with antidepressant treatments, we hypothesized that antidepressants may regulate the expression and activity of MMP-2/9 and TIMPs 1-4.
Gene_expression (expression) of MMP-2 associated with antidepressant
17) Confidence 0.59 Published 2008 Journal Synapse Section Abstract Doc Link 18509851 Disease Relevance 0.17 Pain Relevance 0.70
ProMMP-2 was detected in all experimental groups.
Gene_expression (detected) of ProMMP-2
18) Confidence 0.56 Published 2002 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 11757011 Disease Relevance 0.16 Pain Relevance 0
The corneas were excised and processed for immunohistochemical staining, Western blot assay, and zymography studies to determine the localization of the production of the following matrix metalloproteinases (MMPs): MMP-1, MMP-2, MMP-8, and MMP-9.
Spec (determine) Gene_expression (production) of MMP-2 in corneas
19) Confidence 0.56 Published 2003 Journal J Cataract Refract Surg Section Body Doc Link 12781288 Disease Relevance 0.06 Pain Relevance 0
MMP2 level in tracheal aspirates
Gene_expression (level) of MMP2
20) Confidence 0.54 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.92 Pain Relevance 0

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