INT295035

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Context Info
Confidence 0.22
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.87
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cdk2) cytoplasm (Cdk2) cytosol (Cdk2)
mitosis (Cdk2) nucleus (Cdk2) cytoskeleton (Cdk2)
Cdk2 (Mus musculus)
Pain Link Frequency Relevance Heat
palliative 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 5 97.92 Very High Very High Very High
Apoptosis 32 90.72 High High
Cancer 93 85.04 High High
Targeted Disruption 1 78.92 Quite High
Toxicity 3 67.64 Quite High
Syndrome 1 65.32 Quite High
Cytomegalovirus Infection 66 5.00 Very Low Very Low Very Low
Infection 26 5.00 Very Low Very Low Very Low
Melanoma 15 5.00 Very Low Very Low Very Low
Metastasis 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Maddika et al indicated that inhibitors of PI3-kinase or Akt not only inhibited CDK2 activation but also protected cells from Apoptin-induced cell death, and Akt-mediated activation of CDK2 was caused by direct phosphorylation as well as by the phosphorylation-induced degradation of its inhibitor p27 (Kip1) [32].
Negative_regulation (inhibited) of Positive_regulation (activation) of CDK2 associated with death
1) Confidence 0.22 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 0.87 Pain Relevance 0

General Comments

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