INT295038

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Context Info
Confidence 0.29
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 6.39
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ebi3) extracellular region (Ebi3)
Anatomy Link Frequency
B-lymphocytes 1
THP-1 1
fibroblasts 1
bowel 1
keratinocytes 1
Ebi3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 42 98.88 Very High Very High Very High
cytokine 164 93.60 High High
rheumatoid arthritis 4 86.28 High High
Arthritis 4 73.48 Quite High
chemokine 12 5.00 Very Low Very Low Very Low
tolerance 12 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaemia 2 100.00 Very High Very High Very High
Inflammatory Bowel Disease 8 99.64 Very High Very High Very High
Infection 204 99.12 Very High Very High Very High
INFLAMMATION 42 98.44 Very High Very High Very High
Epstein-barr Virus 4 98.36 Very High Very High Very High
Cancer 190 98.04 Very High Very High Very High
Malignant Neoplastic Disease 10 97.04 Very High Very High Very High
Hepatocellular Cancer 2 95.32 Very High Very High Very High
Lymphatic System Cancer 2 94.88 High High
Cholangiocarcinoma 2 94.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The EBi3 gene was first identified in 1996, following its expression during B-lymphocytes infection with the Epstein Barr Virus.
Gene_expression (expression) of EBi3 in B-lymphocytes associated with epstein-barr virus and infection
1) Confidence 0.29 Published 2011 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2963117 Disease Relevance 0.29 Pain Relevance 0.28
EBi3 and p35 are both highly expressed by mouse Treg cells, thus seemingly providing a key component of the immune regulating function of these cells.
Gene_expression (expressed) of EBi3
2) Confidence 0.29 Published 2011 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2963117 Disease Relevance 0.84 Pain Relevance 0.31
Furthermore, in the absence of EBi3 or p35 subunit production, Treg cells are unable to resolve gut inflammation in mouse inflammatory bowel disease (IBD) [49].
Gene_expression (production) of EBi3 in bowel associated with inflammatory bowel disease and inflammation
3) Confidence 0.29 Published 2011 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2963117 Disease Relevance 0.75 Pain Relevance 0.32
Recent experiments performed in our laboratory (unpublished data) have shown that when THP-1 cells are challenged with heat killed C. albicans, an enhanced expression of EBi3 (a subunit of both IL-27 and IL-35) occurs compared with exposure to bacterial lipopolysaccharide alone (Figure 2(a)).
Gene_expression (expression) of EBi3 in THP-1
4) Confidence 0.22 Published 2011 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2963117 Disease Relevance 0.81 Pain Relevance 0.06
Apoptin, the product of the chicken anemia virus VP3 gene, shows specificity and efficiency toward a wide range of transformed and malignant cells of human origin, including hepatomas, lymphomas, cholangiocarcinomas, melanomas, and breast, lung, and colon carcinomas, while sparing non-transformed primary cells such as fibroblasts, keratinocytes, or smooth muscle cells [12-14].
Gene_expression (product) of virus VP3 gene in keratinocytes associated with malignant neoplastic disease, cholangiocarcinoma, lymphatic system cancer, anaemia, melanoma, colon cancer and hepatocellular cancer
5) Confidence 0.01 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 1.85 Pain Relevance 0
Apoptin, the product of the chicken anemia virus VP3 gene, shows specificity and efficiency toward a wide range of transformed and malignant cells of human origin, including hepatomas, lymphomas, cholangiocarcinomas, melanomas, and breast, lung, and colon carcinomas, while sparing non-transformed primary cells such as fibroblasts, keratinocytes, or smooth muscle cells [12-14].
Gene_expression (product) of virus VP3 gene in fibroblasts associated with malignant neoplastic disease, cholangiocarcinoma, lymphatic system cancer, anaemia, melanoma, colon cancer and hepatocellular cancer
6) Confidence 0.00 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 1.85 Pain Relevance 0

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