INT295038

Context Info Confidence 0.29 First Reported 2010 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 6 Disease Relevance 6.39 Pain Relevance 0.97

extracellular space (Ebi3) extracellular region (Ebi3)

Anatomy Link Frequency B-lymphocytes 1 THP-1 1 fibroblasts 1 bowel 1 keratinocytes 1 Ebi3 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 42 98.88 cytokine 164 93.60 rheumatoid arthritis 4 86.28 Arthritis 4 73.48 chemokine 12 5.00 tolerance 12 5.00 Inflammatory response 8 5.00 corticosteroid 4 5.00 Pain 4 5.00 palliative 2 5.00

Disease Link Frequency Relevance Heat Anaemia 2 100.00 Inflammatory Bowel Disease 8 99.64 Infection 204 99.12 INFLAMMATION 42 98.44 Epstein-barr Virus 4 98.36 Cancer 190 98.04 Malignant Neoplastic Disease 10 97.04 Hepatocellular Cancer 2 95.32 Lymphatic System Cancer 2 94.88 Cholangiocarcinoma 2 94.44

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The EBi3 gene was first identified in 1996, following its expression during B-lymphocytes infection with the Epstein Barr Virus.

Gene_expression (expression) of EBi3 in B-lymphocytes associated with epstein-barr virus and infection

1) Confidence 0.29 Published 2011 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2963117 Disease Relevance 0.29 Pain Relevance 0.28

EBi3 and p35 are both highly expressed by mouse Treg cells, thus seemingly providing a key component of the immune regulating function of these cells.

Gene_expression (expressed) of EBi3

2) Confidence 0.29 Published 2011 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2963117 Disease Relevance 0.84 Pain Relevance 0.31

Furthermore, in the absence of EBi3 or p35 subunit production, Treg cells are unable to resolve gut inflammation in mouse inflammatory bowel disease (IBD) [49].

Gene_expression (production) of EBi3 in bowel associated with inflammatory bowel disease and inflammation

3) Confidence 0.29 Published 2011 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2963117 Disease Relevance 0.75 Pain Relevance 0.32

Recent experiments performed in our laboratory (unpublished data) have shown that when THP-1 cells are challenged with heat killed C. albicans, an enhanced expression of EBi3 (a subunit of both IL-27 and IL-35) occurs compared with exposure to bacterial lipopolysaccharide alone (Figure 2(a)).

Gene_expression (expression) of EBi3 in THP-1

4) Confidence 0.22 Published 2011 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2963117 Disease Relevance 0.81 Pain Relevance 0.06

Apoptin, the product of the chicken anemia virus VP3 gene, shows specificity and efficiency toward a wide range of transformed and malignant cells of human origin, including hepatomas, lymphomas, cholangiocarcinomas, melanomas, and breast, lung, and colon carcinomas, while sparing non-transformed primary cells such as fibroblasts, keratinocytes, or smooth muscle cells [12-14].

Gene_expression (product) of virus VP3 gene in keratinocytes associated with malignant neoplastic disease, cholangiocarcinoma, lymphatic system cancer, anaemia, melanoma, colon cancer and hepatocellular cancer

5) Confidence 0.01 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 1.85 Pain Relevance 0

Apoptin, the product of the chicken anemia virus VP3 gene, shows specificity and efficiency toward a wide range of transformed and malignant cells of human origin, including hepatomas, lymphomas, cholangiocarcinomas, melanomas, and breast, lung, and colon carcinomas, while sparing non-transformed primary cells such as fibroblasts, keratinocytes, or smooth muscle cells [12-14].

Gene_expression (product) of virus VP3 gene in fibroblasts associated with malignant neoplastic disease, cholangiocarcinoma, lymphatic system cancer, anaemia, melanoma, colon cancer and hepatocellular cancer

6) Confidence 0.00 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 1.85 Pain Relevance 0

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