INT295095

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Context Info
Confidence 0.68
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 2.04
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pou1f1) DNA binding (Pou1f1) transcription factor binding (Pou1f1)
cytoplasm (Pou1f1)
Anatomy Link Frequency
liver 2
osteoblast 2
embryo 1
Pou1f1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 9 67.60 Quite High
cva 18 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
isoflurane 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 126 100.00 Very High Very High Very High
Anaemia 126 99.98 Very High Very High Very High
Osteoporosis 45 99.68 Very High Very High Very High
Diphtheria 9 88.92 High High
Death 45 86.80 High High
Calcification 54 82.16 Quite High
Embryonic Lethality 72 76.16 Quite High
Osteoarthritis 9 67.60 Quite High
Hematological Disease 18 50.32 Quite High
Leukemia 9 35.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, PiT1, but not PiT2 is upregulated during osteoblast differentiation [15].
Positive_regulation (upregulated) of PiT1 in osteoblast associated with osteoporosis
1) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.41 Pain Relevance 0
Importantly, PiT1, but not PiT2 is upregulated during osteoblast differentiation, consistent with a dedicated role of PiT1 in this process [15].
Positive_regulation (upregulated) of PiT1 in osteoblast associated with osteoporosis
2) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.39 Pain Relevance 0.03
EcoRV digested genomic DNA from 336 ES clones was screened by Southern blotting using a PiT1 5?
Positive_regulation (using) of PiT1
3) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.09 Pain Relevance 0
5 hematopoietic committed progenitor cells were able to proliferate and differentiate normally when tested in vitro, this suggests that the anemia seen in E12.5 PiT1?
Positive_regulation (seen) of PiT1 associated with anaemia
4) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.27 Pain Relevance 0
However, when results were expressed as number of colonies per 105 nucleated fetal-liver cells, no significant difference was found between normal and mutant livers suggesting that a similar fraction of PiT1?
Positive_regulation (fraction) of PiT1 in livers
5) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0 Pain Relevance 0
Increased Apoptosis and Reduced Growth Rate in PiT1?
Positive_regulation (Increased) of PiT1 associated with apoptosis
6) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.28 Pain Relevance 0
Our results clearly show that the embryo forms, develops and grows without major defects until E11.5 in the absence of PiT1, which demonstrates that PiT1 is dispensable for early development.
Positive_regulation (dispensable) of PiT1 in embryo
7) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.32 Pain Relevance 0
Our results show that, although PiT2 expression is unchanged, PiT1 is highly (3.5-fold) induced within 2 h following partial hepatectomy (Fig. 7F) indicating that PiT1 is likely to be essential during the early stage of compensatory liver growth.
Positive_regulation (induced) of PiT1 in liver
8) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.06 Pain Relevance 0
Derivation of PiT1 Genetically Modified Mice
Positive_regulation (Derivation) of PiT1
9) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.22 Pain Relevance 0

General Comments

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