INT295096

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Context Info
Confidence 0.79
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.48
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pou1f1) DNA binding (Pou1f1) transcription factor binding (Pou1f1)
cytoplasm (Pou1f1)
Anatomy Link Frequency
livers 2
vasculature 2
embryo 1
Pou1f1 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 10 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
isoflurane 5 5.00 Very Low Very Low Very Low
Osteoarthritis 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Calcification 30 100.00 Very High Very High Very High
Hematological Disease 10 99.28 Very High Very High Very High
Death 25 94.12 High High
Apoptosis 70 82.32 Quite High
Osteoporosis 25 82.24 Quite High
Anaemia 70 77.72 Quite High
Embryonic Lethality 40 67.48 Quite High
Congenital Anomalies 20 5.00 Very Low Very Low Very Low
Hemorrhage 10 5.00 Very Low Very Low Very Low
Sprains And Strains 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, PiT1 has been localized in adult hepatocytes, but not in cholangiocytes, in rat livers [36].
Neg (not) Localization (localized) of PiT1 in livers
1) Confidence 0.79 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0 Pain Relevance 0
In summary, although PiT1 does not seem to be essential to the development of a normal vasculature, it remains to be determined whether PiT1 is instrumental to a Pi-induced vascular calcification in vivo through the generation of animals carrying a tissue-specific deletion of PiT1.
Localization (deletion) of PiT1 in vasculature associated with calcification
2) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.49 Pain Relevance 0
In summary, although PiT1 does not seem to be essential to the development of a normal vasculature, it remains to be determined whether PiT1 is instrumental to a Pi-induced vascular calcification in vivo through the generation of animals carrying a tissue-specific deletion of PiT1.
Localization (deletion) of PiT1 in vasculature associated with calcification
3) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.47 Pain Relevance 0
Our results clearly show that the embryo forms, develops and grows without major defects until E11.5 in the absence of PiT1, which demonstrates that PiT1 is dispensable for early development.
Neg (absence) Localization (absence) of PiT1 in embryo
4) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.27 Pain Relevance 0
Livers from E11.5 and E12.5 PiT1?
Localization (Livers) of PiT1 in Livers
5) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.24 Pain Relevance 0

General Comments

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