INT295102

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.97
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pou1f1) DNA binding (Pou1f1) transcription factor binding (Pou1f1)
cytoplasm (Pou1f1)
Anatomy Link Frequency
vasculature 4
Pou1f1 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Calcification 12 100.00 Very High Very High Very High
Death 10 94.12 High High
Osteoporosis 10 82.24 Quite High
Anaemia 28 77.72 Quite High
Embryonic Lethality 16 67.48 Quite High
Apoptosis 28 5.00 Very Low Very Low Very Low
Congenital Anomalies 8 5.00 Very Low Very Low Very Low
Hematological Disease 4 5.00 Very Low Very Low Very Low
Hemorrhage 4 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, although PiT1 does not seem to be essential to the development of a normal vasculature, it remains to be determined whether PiT1 is instrumental to a Pi-induced vascular calcification in vivo through the generation of animals carrying a tissue-specific deletion of PiT1.
Positive_regulation (induced) of Localization (deletion) of PiT1 in vasculature associated with calcification
1) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.49 Pain Relevance 0
In summary, although PiT1 does not seem to be essential to the development of a normal vasculature, it remains to be determined whether PiT1 is instrumental to a Pi-induced vascular calcification in vivo through the generation of animals carrying a tissue-specific deletion of PiT1.
Positive_regulation (induced) of Localization (deletion) of PiT1 in vasculature associated with calcification
2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.49 Pain Relevance 0

General Comments

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