INT295162

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 1.69
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcb1b) mitochondrion (Abcb1b) ATPase activity (Abcb1b)
transmembrane transport (Abcb1b)
Anatomy Link Frequency
band 1
Abcb1b (Mus musculus)
Pain Link Frequency Relevance Heat
alcohol 3 79.52 Quite High
tolerance 8 77.36 Quite High
vincristine 6 73.00 Quite High
anesthesia 11 31.36 Quite Low
cytokine 6 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 21 98.88 Very High Very High Very High
Toxicity 3 88.04 High High
Body Weight 3 88.04 High High
Infection 29 86.16 High High
Cancer 76 83.44 Quite High
Injury 3 81.72 Quite High
Malaria 40 75.20 Quite High
Falciparum Malaria 5 62.56 Quite High
Leukemoid Reaction 3 35.76 Quite Low
Recurrence 5 31.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Either of these outcomes could perturb the overall regulation of mdr1 mRNA and protein expression.
Transcription (expression) of mdr1
1) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904698 Disease Relevance 0.14 Pain Relevance 0
In order to determine whether the increase in genomic copies and transcription of the mdr1 gene was accompanied by an increase in its product, we measured the relative amount of MDR1 protein in the different parasite clones, using quantitative Western blot analysis.
Transcription (transcription) of mdr1
2) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904698 Disease Relevance 0 Pain Relevance 0
Thus, the fold-increase of AS-ATNMF1 mdr1 mRNA transcripts was 2.6±0.17 and 3.4±0.22, relative to its single copy number progenitor AS-ATN and to AS-3CQ, respectively.
Transcription (transcripts) of mdr1
3) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904698 Disease Relevance 0 Pain Relevance 0
The biodistribution of human MDR1 by in situ hybridization was consistent with the expression of P-gp.
Transcription (biodistribution) of MDR1
4) Confidence 0.51 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2819043 Disease Relevance 0.33 Pain Relevance 0.04
Detection of human MDR1 gene biodistribution
Transcription (biodistribution) of MDR1
5) Confidence 0.51 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2819043 Disease Relevance 0.75 Pain Relevance 0.04
In this context, we investigated by real time PCR whether the evolution of ATN + MF-resistance had selected parasites with increased mdr1 copy number or mRNA expression.
Transcription (expression) of mdr1
6) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904698 Disease Relevance 0 Pain Relevance 0.04
Investigation of candidate genes revealed an mdr1 duplication in the resistant parasites and increased levels of mdr1 transcripts and protein.
Transcription (transcripts) of mdr1
7) Confidence 0.44 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2904698 Disease Relevance 0.21 Pain Relevance 0
(Figure 1) MDR1 mRNA highly expressed in the treated BMCs which showed a unique MDR1 specific band compared with the untreated cells.
Transcription (expressed) of MDR1 in band
8) Confidence 0.34 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2819043 Disease Relevance 0.26 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox