INT295165

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.30
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Adcy1) nucleus (Adcy1)
Anatomy Link Frequency
synapses 1
Adcy1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 32 98.28 Very High Very High Very High
Neuropathic pain 2 96.66 Very High Very High Very High
Inflammation 6 90.92 High High
IPN 3 84.24 Quite High
long-term potentiation 9 78.40 Quite High
nMDA receptor 4 70.92 Quite High
allodynia 1 65.28 Quite High
Lasting pain 5 56.80 Quite High
Analgesic 11 53.08 Quite High
depression 4 52.12 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 2 99.96 Very High Very High Very High
Nervous System Injury 2 98.84 Very High Very High Very High
Neuropathic Pain 3 96.66 Very High Very High Very High
Amputation 2 91.48 High High
INFLAMMATION 9 90.92 High High
Inflammatory Pain 3 84.24 Quite High
Injury 4 69.36 Quite High
Pain 20 56.80 Quite High
Respiratory Failure 4 52.12 Quite High
Nociception 26 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The animal model of neuropathic pain shows that postsynaptic AMPA receptor mediated responses are enhanced in the ACC synapses, such nerve injury triggered enhancement of postsynaptic responses could be abolished in AC1 knockout mice [40], suggesting that AC1 may serve as a potential therapeutic target for treating neuropathic pain.
Negative_regulation (abolished) of AC1 in synapses associated with targeted disruption, nervous system injury, neuropathic pain and anterior cingulate cortex
1) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819047 Disease Relevance 1.30 Pain Relevance 1.13

General Comments

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