INT295241

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Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.44
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Srxn1) oxidoreductase activity (Srxn1) DNA binding (Srxn1)
cytoplasm (Srxn1)
Srxn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 4 73.04 Quite High
Inflammation 66 59.60 Quite High
cytokine 12 5.00 Very Low Very Low Very Low
Inflammatory marker 6 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 10 89.68 High High
INFLAMMATION 78 73.04 Quite High
Disease 6 46.40 Quite Low
Apoptosis 40 23.36 Low Low
Drug Induced Neurotoxicity 10 5.00 Very Low Very Low Very Low
Acute-phase Reaction 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Demyelinating Disease 2 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, we speculate that increased microglial expression of Srxn1, Blvrb, and Gclm is also mediated by activation of Nrf2.
Positive_regulation (mediated) of Gene_expression (expression) of Srxn1
1) Confidence 0.32 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819254 Disease Relevance 0.22 Pain Relevance 0.07
Therefore, we speculate that increased microglial expression of Srxn1, Blvrb, and Gclm is also mediated by activation of Nrf2.
Positive_regulation (increased) of Gene_expression (expression) of Srxn1
2) Confidence 0.32 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819254 Disease Relevance 0.21 Pain Relevance 0.06

General Comments

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