INT295261

Context Info Confidence 0.17 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.49 Pain Relevance 0.13

nucleus (Hmox1, Nfe2l2) endoplasmic reticulum (Hmox1) DNA binding (Nfe2l2) enzyme binding (Hmox1) cytoplasm (Nfe2l2) signal transducer activity (Hmox1)

Hmox1 (Mus musculus) Nfe2l2 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 66 64.64 Inflammatory response 4 39.36 cytokine 12 5.00 Inflammatory marker 6 5.00 Spinal cord 2 5.00 cINOD 2 5.00 Neurotransmitter 2 5.00 Multiple sclerosis 2 5.00 chemokine 2 5.00 Glutamate 2 5.00

Disease Link Frequency Relevance Heat Disease 6 65.00 INFLAMMATION 78 64.64 Neurodegenerative Disease 10 56.00 Apoptosis 40 41.96 Drug Induced Neurotoxicity 10 5.00 Acute-phase Reaction 4 5.00 Stress 4 5.00 Demyelinating Disease 2 5.00 Toxicity 2 5.00 Death 2 5.00

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Stimulation with the flavonoid induced binding of the transcription factor NF-E2-related factor 2 (Nrf2) to anti-oxidant response elements (ARE) in the Hmox1 promoter region [60].

Hmox1 Binding (binding) of Nrf2

1) Confidence 0.17 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819254 Disease Relevance 0.25 Pain Relevance 0.06

Stimulation with the flavonoid induced binding of the transcription factor NF-E2-related factor 2 (Nrf2) to anti-oxidant response elements (ARE) in the Hmox1 promoter region [60].

Hmox1 Binding (binding) of NF-E2-related

2) Confidence 0.17 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819254 Disease Relevance 0.25 Pain Relevance 0.06

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