INT295272

Context Info Confidence 0.00 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.63 Pain Relevance 0.14

nucleoplasm (STAT1) Golgi apparatus (Hp) endoplasmic reticulum (Hp) enzyme binding (STAT1) cytoplasm (STAT1) signal transducer activity (STAT1)

STAT1 (Homo sapiens) Hp (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 33 99.18 cytokine 6 62.32 Inflammatory response 2 18.68 Inflammatory marker 3 5.00 Spinal cord 1 5.00 cINOD 1 5.00 Neurotransmitter 1 5.00 Multiple sclerosis 1 5.00 chemokine 1 5.00 Glutamate 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 39 99.18 Apoptosis 20 80.64 Aging 1 68.32 Stress 2 57.76 Neurodegenerative Disease 5 10.56 Drug Induced Neurotoxicity 5 5.00 Disease 3 5.00 Acute-phase Reaction 2 5.00 Demyelinating Disease 1 5.00 Toxicity 1 5.00

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Luteolin also diminished mRNA levels of the pro-inflammatory GTPase Gbp2 and the acute phase protein Haptoglobin, which are both regulated by signal transducers and activators of transcription (STATs) [70,71].

signal transducers and activators of transcription Regulation (regulated) of Haptoglobin associated with inflammation

1) Confidence 0.00 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819254 Disease Relevance 0.63 Pain Relevance 0.14

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